341273

Factor D, Human

Factor D, Human, is a native single-chain glycoprotein with serine protease activity. Cleaves, and thus activates, Factor B during activation of complement via the alternative pathway.

• Synonym(e): C3 Activator Convertase, Adipsin
• UNSPSC-Code: 12352202
• NACRES: NA.25

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥90% (SDS-PAGE)
• Form: liquid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; avoid repeated freeze/thaw cycles
• Versandbedingung: wet ice
• Lagertemp.: −70°C

Beschreibung

Allgemeine Beschreibung

Native factor D from human serum. Single-chain glycoprotein composed of 222 amino acids present in normal human serum at about 1.4 µg/ml. Serine protease that cleaves, and thus activates, Factor B during activation of complement via the alternative pathway. Has recently been shown to be identical to adipsin, a serine protease secreted into the bloodstream by adipocytes.

Native factor D from human serum. Single-chain glycoprotein composed of 222 amino acids, present in normal human serum at about 1.4 µg/ml. Serine protease that cleaves, and thus activates, Factor B during activation of complement via the alternative pathway. Has recently been shown to be identical to adipsin, a serine protease secreted into the bloodstream by adipocytes.

Biochem./physiol. Wirkung

IgG, IgA, IgM, Factor H, Factor B, or albumin: ≤trace amounts

Warnhinweis

Toxicity: Standard Handling (A)

Physikalische Form

In PBS, pH 7.2.

Angaben zur Herstellung

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Rekonstituierung

Following initial thaw, aliquot and freeze (-70°C).

Sonstige Hinweise

Jing, H., et al. 1999. EMBO J.18, 804.
Volankis, J.E., et al. 1985. N. Engl. J. Med. 312, 395.
Niemann, M.A., et al. 1984. J. Immunol. 132, 809.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable