324623

Eg5 Inhibitor IV, VS-83

The Eg5 Inhibitor IV, VS-83, also referenced under CAS 909250-29-9, controls the biological activity of Eg5. This small molecule/inhibitor is primarily used for Cell Structure applications.

• Synonym(e): Eg5 Inhibitor IV, VS-83, 5-Fluoro-3,4-dihydro-4(3ʹ-hydroxyphenyl)quinazoline-2(1H)-thione
• Empirische Formel (Hill-System): C₁₄H₁₁FN₂OS
• CAS-Nummer: 909250-29-9
• Molekulargewicht: 274.31
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥99% (HPLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: white
• Löslichkeit: ethanol: 5 mg/mL; DMSO: 50 mg/mL
• Versandbedingung: ambient
• Lagertemp.: −20°C
• InChI: 1S/C14H11FN2OS/c15-10-5-2-6-11-12(10)13(17-14(19)16-11)8-3-1-4-9(18)7-8/h1-7,13,18H,(H2,16,17,19)
• InChIKey: MAEYCDNDKNPNQJ-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A cell-permeable Monastrol (Cat. No. 475879) analog with much enhanced potency and selectivity (over 8 other kinesins) in inhibiting mitotic kinesin Eg5-ATPase activity (IC₅₀ = 1.17 vs. 20.73 µM for VS-83 and Monastrol, respectively) and in inducing monoasters formation (EC₅₀ = 7.27 vs. 58.74 µM for BSC-1 cells treated with VS-83 and Monastrol, respectively). Shown to exhibit ≥10-fold antiproliferative activity than Monastrol against U-87 MG, U-118 MG, and U-373 MG glioblastoma cells.

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Regulatory Review (Z)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Muller, C., et al. 2007. Cancer Chemother. Pharmacol.59, 157.
Santamaria, A., et al. 2007. Mol. Biol. Cell18, 4024.
Sarli, V., et al. 2005. ChemBioChem6, 2005.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable