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Key Documents

14-595-M

Sigma-Aldrich

PP1α Protein, 10 µg

Recombinant, full length, human PP1α, for use in Phosphatase Assays.

Synonym(e):

PPP1C, Phosphoprotein phosphatase 1, Phosphorylase phosphatase

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise


About This Item

UNSPSC-Code:
12352200
eCl@ss:
32160405
NACRES:
NA.32

Biologische Quelle

human

Qualitätsniveau

Rekombinant

expressed in E. coli

Form

solution

Haltbarkeit

6 mo.

Mol-Gew.

Mw 37.6 kDa

Hersteller/Markenname

Upstate®

Methode(n)

activity assay: suitable (phosphatase)

Löslichkeit

water: soluble

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Lagertemp.

−20°C

Angaben zum Gen

human ... PPP1CA(5499)

Allgemeine Beschreibung

Research area: Neuroscience
Protein Phosphatase 1 (PP1) is one of the key serine/threonine-specific protein phosphatases.

Anwendung

Research Category
Entzündung & Immunologie

Biochem./physiol. Wirkung

Protein Target: PP1α Target Sub-Family: Ser/Thr phosphatase

Protein Phosphatase 1 (PP1) has been associated with a wide range of biological processes, including synaptic plasticity, cell cycle progression, dopaminergic neurotransmission, contraction, and glycogen metabolism, maintaining microtubule stability and the dephosphorylation of tau. Furthermore, PP-1 plays a vital role in synaptic development, plasticity, signaling, neurite outgrowth, synapse formation, ion channel function, and neurotransmission. Changes in PP-1 signaling within dendritic spines have been linked to various neurological and psychiatric disorders.

Verpackung

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-595M when ordering the 250 µg size.

Qualität

routinely evaluated by dephosphorylation of 100μM DiFMUP

Physikalische Form

Heparin agarose followed by Q agarose

Lagerung und Haltbarkeit

6 months at -20°C from date of shipment

Sonstige Hinweise

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme

Rechtliche Hinweise

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Piktogramme

Exclamation mark

Signalwort

Warning

H-Sätze

Gefahreneinstufungen

Skin Sens. 1

Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 1


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

The role of protein phosphatase-1 in the modulation of synaptic and structural plasticity.
Munton, Richard P, et al.
Febs Letters, 567, 121-128 (2004)
Alphonse Garcia et al.
Biochimie, 85(8), 721-726 (2003-10-31)
The reversible phosphorylation of proteins controlled by protein kinases and protein phosphatases is a major mechanism that regulates a wide variety of cellular processes. In contrast to C. elegans, recent studies in mammalian cells have highlighted a major role of
Hugo Ceulemans et al.
Physiological reviews, 84(1), 1-39 (2004-01-13)
The protein serine/threonine phosphatase protein phosphatase-1 (PP1) is a ubiquitous eukaryotic enzyme that regulates a variety of cellular processes through the dephosphorylation of dozens of substrates. This multifunctionality of PP1 relies on its association with a host of function-specific targetting
Patricia T W Cohen
Journal of cell science, 115(Pt 2), 241-256 (2002-02-13)
Protein phosphatase 1 (PP1) is a major eukaryotic protein serine/threonine phosphatase that regulates an enormous variety of cellular functions through the interaction of its catalytic subunit (PP1c) with over fifty different established or putative regulatory subunits. Most of these target

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