07-574

Anti-CENP-A Antibody

Upstate^®, from rabbit

• Synonym(e): Anti-CENP-A, Anti-CenH3
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörperform: affinity purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Aufgereinigt durch: affinity chromatography
• Speziesreaktivität: human
• Hersteller/Markenname: Upstate^®
• Methode(n): western blot: suitable
• Isotyp: IgG
• NCBI-Hinterlegungsnummer: NM_001809
• UniProt-Hinterlegungsnummer: P49450
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... CENPA(1058)

Beschreibung

Allgemeine Beschreibung

CENP-A is a variant version of histone H3 found only at centromeres.

Centromere protein A (CENP-A) is a 17 kDa centromere-specific histone variant with 62% amino acids homology to the C-terminal of histone H3. Localized in the centromere, it plays a central role in the centromere-specific chromatin formation. The depletion of histone H3 at the CENP-A binding domain suggests CENP-A to be a possible replacement for histone H3 in the packaging process of α-satellite DNA into primary chromation structure. CENP-A is essential in the formation of specialized nucleosomes at the centromere, implicating CENP-A as a centromere-specific epigenetic marker.

Spezifität

Broad species cross-reactivity is predicted.

CENP-A

Immunogen

peptide (RRRSRKPEAPRRRS) corresponding to amino acids 4-17 of human CENP-A

Anwendung

Research Category
Epigenetik & nukleäre Funktionen

Research Sub Category
Zellzyklus, DNA-Replikation & -Reparatur

Anti-CENP-A Antibody is a Rabbit Polyclonal Antibody for detection of CENP-A also known as Centromere autoantigen A & has been tested in WB.

Qualität

routinely evaluated by immunoblot in acid extracted histones from HeLa cells

Zielbeschreibung

17kDa

Verlinkung

Replaces: 04-205

Physikalische Form

ImmunoAffinity Purified

Affinity purified immunoglobulin in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2 to 8ºC from date of receipt.

Hinweis zur Analyse

Control
Control Histones (from Hela cells) colcemid-treated or untreated

Rechtliche Hinweise

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1