07-276

Anti-PDGFRα Antibody

Upstate^®, from rabbit

• Synonym(e): Anti-Anti-CD140A, Anti-Anti-PDGFR-2, Anti-Anti-PDGFR2
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörperform: affinity purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Aufgereinigt durch: affinity chromatography
• Speziesreaktivität: human, mouse
• Verpackung: antibody small pack of 25 μL
• Hersteller/Markenname: Upstate^®
• Methode(n): immunoprecipitation (IP): suitable; western blot: suitable
• Isotyp: IgG
• NCBI-Hinterlegungsnummer: NM_011058
• UniProt-Hinterlegungsnummer: P16234
• Versandbedingung: ambient
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... PDGFRA(5156)

Beschreibung

Allgemeine Beschreibung

Platelet derived growth factor receptor (PDGF Receptor) is a transmembrane glycoprotein of 170-185 kDa which undergoes homo or heterodimerization into complexes of alpha and beta subunits upon ligand binding, depending on the isoform of PDGF (PDGF AA, BB or AB) that binds. The phosphorylation of tyrosine residues in the now activated receptor can control multiple signaling events such as actin reorganization, transcription, cell growth, migration and differentiation, and also lead to activation of the Ras, Raf and ERK 1 and 2 pathway.

Spezifität

Recognizes PDGF Receptor alpha.

Immunogen

peptide corresponding to amino acids 1035-1053 (C-GKRNRHSSQTSEESAIETG) of human PDGF Receptor α

Anwendung

Research Category
Zelluläre Signaltransduktion

Research Sub Category
Wachstumsfaktoren & -rezeptoren

Detect PDGFRα using this Anti-PDGFRα Antibody validated for use in IP & WB.

Qualität

routinely evaluated by immunoblot on 3T3/NIH cell lysate

Zielbeschreibung

150/170 kDa (doublet)

Physikalische Form

ImmunoAffinity Purified

Protein A Purified immunoglobulin in 0.14 M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Hinweis zur Analyse

Control
HeLa cells, extracts from 3T3/NIH or HepG2 cells, human brain tissue

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Rechtliche Hinweise

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.