07-1497

Anti-cAMP Antibody

serum, from rabbit

• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörperform: serum
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Speziesreaktivität: rat
• Speziesreaktivität (Voraussage durch Homologie): all
• Methode(n): immunohistochemistry: suitable (paraffin)
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified

Beschreibung

Allgemeine Beschreibung

Cyclic adenosine monophosphate or cAMP is an intracellular by-product of ATP by adenylene cyclase when G-protein Coupled Receptors (GPCR) bind various ligands on the cell surface. Cyclic AMP acts as a second messenger for signal transduction across the cell membrane and is a part of kinase activation. It regulates the effects of glucagon and adrenaline along with the movement of calcium ions through ion channels. Since it is affected directly by GPCR activation, cAMP is studied as a means to monitor GPCR in the discovery of therapeutic drugs.

Spezifität

Specific for cAMP with no cross reaction to other nucleotides at concentrations to 1 mM. Reactive with cAMP fixed in tissues or acetylated cAMP. Not reactive with free, non-acetylated, cAMP in RIA or EIA assays.

Immunogen

2′O-succinyl cyclic AMP conjugated to BSA

Anwendung

Research Category
Zelluläre Signaltransduktion

Research Sub Category
GPCR-, cAMP/cGMP- & kalziumabhängige Signalübertragung

Anti-cAMP Antibody detects level of cAMP & has been published & validated for use in IH(P).

Qualität

Evaluated by Immunohistochemistry in rat hippocampus and cerebellum tissue.
Immunohistochemistry Analysis: 1:100 dilution of this lot detected cAMP in rat hippocampus and cerebellum tissue.

Verlinkung

Replaces: MABN1026

Physikalische Form

Unpurified rabbit serum

Diluted serum presented as liquid in PBS containing no preservatives.

Lagerung und Haltbarkeit

Maintain at -20°C in undiluted aliquots from date of shipment. Avoid repeated freeze/thaw cycles.

Hinweis zur Analyse

Control
Rat hippocampus and cerebellum tissue

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable