07-1378

Anti-QIK (SIK2) Antibody

Upstate^®, from rabbit

• Synonym(e): Qin-induced kinase, SNF1-like kinase 2, Salt-inducible protein kinase 2, salt-inducible kinase 2, salt-inducible serine/threonine kinase 2
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Antikörperform: purified antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Speziesreaktivität: rat, canine, mouse, chicken, bovine, human
• Hersteller/Markenname: Upstate^®
• Methode(n): western blot: suitable
• NCBI-Hinterlegungsnummer: NP_056006
• UniProt-Hinterlegungsnummer: Q9H0K1
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... SIK2(23235)

Beschreibung

Allgemeine Beschreibung

QIK (Qin-induced Kinase, SNF1LK2, SIK2, Salt-induced protein Kinase 2) is a Ser/Thr kinase that belongs to the AMPK/SNF1 kinase family. QIK is phosphorylated and activated by the tumor suppressor LKB1 when in complex with the pseudokinase STRAD and the scaffolding protein MO25. QIK has been found in adipocytes where it is known to phosphorylate a few substrates that include insulin receptor substrate 1 (IRS1) on Ser794 and TORC2 (also known as CRTC2 and not to be confused with the mTOR complex) on Ser171. The phosphorylation of TORC2 results in its translocation to the nucleus where it binds to CREB.

Spezifität

Close homology with mouse, rat, chicken, dog, and cow.

Detects QIK

Immunogen

KLH-conjugated synthetic peptide corresponding to the C-term of human QIK.

Anwendung

Research Category
Zelluläre Signaltransduktion

Anti-QIK (SIK2) Antibody is an antibody against QIK (SIK2) for use in WB.

Qualität

Western Blot Analysis:
This lot detected QIK at 1:1,000-1:2,000 dilution in HeLa lysates via SDS-PAGE and transferred to PVDF (Immobilon-P).

Zielbeschreibung

104 kDa

Physikalische Form

Protein A purified

Format: Purified

Protein A purified rabbit serum in 0.1M Tris-Glycine (pH7.4) 15mM NaCl, and 0.05% NaN3 with 30% glycerol.

Lagerung und Haltbarkeit

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Hinweis zur Analyse

Control
HeLa Cell Lysate

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Rechtliche Hinweise

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1