06-680-AF555

Anti-Androgen Receptor Antibody, Alexa Fluor^™ 555 Conjugate

from rabbit, ALEXA FLUOR^™ 555

• Synonym(e): Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.45

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Konjugat: ALEXA FLUOR^™ 555
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Speziesreaktivität: human, rat
• Speziesreaktivität (Voraussage durch Homologie): mouse (based on 100% sequence homology), canine (based on 100% sequence homology), horse (based on 100% sequence homology), bovine (based on 100% sequence homology)
• Methode(n): immunocytochemistry: suitable
• NCBI-Hinterlegungsnummer: NP_036634
• UniProt-Hinterlegungsnummer: P15207
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: bovine ... Ar(280675) ; dog ... Ar(403588) ; human ... AR(367) ; mouse ... Ar(11835) ; rat ... Ar(24208)

Beschreibung

Allgemeine Beschreibung

Androgen receptor (UniProt P15207; also known as Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4) is encoded by the Ar (also known as Andr, Nr3c4, Tfm) gene (Gene ID 24208) in rat species. Androgen receptor (AR) is a hormone-activated transcription regulator that plays important roles in normal prostate development and function, as well as in malignant prostate transformation. The binding of an androgenic hormone (testosterone or dihydrotestosterone) induces a conformational change in AR, resulting in its dissociation from heat schock proteins and subsequent translocation from the cytosol to nucleus, where it dimerizes and mediates either transcription activation or repression in a target gene-specific manner. The androgen insensitivity syndrome (AIS) or testicular feminization (TFM) is caused by a mutation of the androgen receptor gene located on the X chromosome.

Immunogen

Epitope: N-terminal modulating region.

KLH-conjugated linear peptide corresponding to the N-terminal sequence of rat androgen receptor.

Anwendung

Research Category
Epigenetik & nukleäre Funktionen

Research Sub Category
Hormone & Rezeptoren

The unconjugated antibody (Cat. No. 06-680) is shown to be suitable also for chromatin immunoprecipitation (ChIP), ChIP-seq, Western blotting, immunoprecipitation, flow cytometry, immunohistochemistry applications.

This Anti-Androgen Receptor Antibody, Alexa Fluor^™ 555 Conjugate is validated for use in Immunocytochemistry for the detection of Androgen Receptor.

Qualität

Evaluated by Immunocytochemistry in T47D cells.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected androgen receptor in T47D human breast cancer cells.

Zielbeschreibung

~110 kDa observed.

Physikalische Form

Affinity purified.

Purified rabbit polyclonal antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Sonstige Hinweise

Concentration: Please refer to lot specific datasheet.

Rechtliche Hinweise

ALEXA FLUOR is a trademark of Life Technologies

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable