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T-075

Supelco

3,3′,5′-Triiodo-L-thyronine (Reverse T3) solution

100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®

Synonym(e):

3,3′,5′-Triiodo-L-thyronine, Reverse T3, rT(3)

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About This Item

Empirische Formel (Hill-System):
C15H12I3NO4
CAS-Nummer:
5817-39-0
Molekulargewicht:
650.97
MDL-Nummer:
MFCD00036864
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329826619
NACRES:
NA.24

Qualität

certified reference material

Qualitätsniveau

300

Form

liquid

Leistungsmerkmale

Snap-N-Spike®/Snap-N-Shoot®

Verpackung

ampule of 1 mL

Hersteller/Markenname

Cerilliant®

Konzentration

100 μg/mL in methanol with 0.1N NH3

Methode(n)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Anwendung(en)

clinical testing
clinical testing

Format

single component solution

Lagertemp.

−20°C

SMILES String

N[C@@H](Cc1ccc(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)/t12-/m0/s1

InChIKey

HZCBWYNLGPIQRK-LBPRGKRZSA-N

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Allgemeine Beschreibung

Reverse T3, also known as rT3 or 3,3′,5′-Triiodo-L-thyronine, is a biologically inactive form of the thyroid hormone T3 and is produced in the body particularly during periods of stress. Under certain conditions such as fibromyalgia, liver disease, and chronic fatigue syndrome (CFS), more rT3 is produced which minimizes the desirable conversion of thyroxine (T4) to T3. Reverse T3 serum concentrations are measured by LC-MS/MS to monitor impact of these and other diseases on thyroid hormone levels.

Anwendung


  • Reverse T3 solution for thyroid research: Reverse T3 (3,3′,5′-Triiodo-L-thyronine) is utilized in biochemical assays to assess thyroid function and metabolism. Its role as an inactive metabolite of thyroid hormone makes it critical in studies investigating thyroid hormone balance and its impact on metabolic rate (Filetti et al., 1980).

  • High-purity rT3 thyroid hormone analog: Due to its high purity and stability, Reverse T3 is essential in thyroid metabolism research, providing a reliable standard for comparing thyroid activity and understanding its biological effects in health and disease states.

  • Thyroid metabolism research using Reverse T3: rT3 is instrumental in the study of thyroid hormone metabolism pathways, particularly in understanding the conversion processes of T4 to T3 and rT3, aiding in deciphering the complex regulatory mechanisms of thyroid hormones.

  • Reverse T3 in comparative endocrinology studies: The application of Reverse T3 solution extends to comparative endocrinology, where it is used to study the variations and similarities in thyroid hormone metabolism among different species, contributing to broader biological and evolutionary insights.

Rechtliche Hinweise

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 3 - Flam. Liq. 2 - STOT SE 1

Zielorgane

Eyes,Central nervous system

Lagerklassenschlüssel

3 - Flammable liquids

WGK

WGK 2

Flammpunkt (°F)

49.5 °F - closed cup

Flammpunkt (°C)

9.7 °C - closed cup

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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S Ruhla et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 43(2), 130-134 (2010-11-26)
Thyroid dysfunction has been shown to be associated with insulin resistance (IR). This may involve peripheral thyroid hormone metabolism, which is assumed to be reflected by the ratio triiodothyronine/reverse triiodothyronine (T3/rT3-ratio). To explore a potential association between the T3/rT3-ratio and
Ashley Hinther et al.
Environmental science & technology, 44(21), 8314-8321 (2010-10-12)
Nanometals are manufactured to particle sizes with diameters in the nanometer range and are included in a variety of consumer and health products. There is a lack of information regarding potential effects of these materials on aquatic organisms. Amphibians are
Annemieke J Lem et al.
The Journal of clinical endocrinology and metabolism, 97(9), 3170-3178 (2012-06-28)
Age-appropriate reference ranges for thyroid hormones are required for detecting pediatric thyroid dysfunction. Data on thyroid hormones and peripheral thyroid metabolism in short children born small for gestational age (SGA) before and during GH treatment are lacking. Our objectives were
R Kassem et al.
Clinical and experimental dermatology, 37(8), 850-856 (2012-10-23)
Different elements of the hypothalamic-pituitary-thyroid axis have been found to be implicated in the normal physiology of the human skin. Their effects on wound healing and hair growth in rats have been described previously. There is close homology between the
Pranati Sar et al.
PloS one, 6(6), e20861-e20861 (2011-06-21)
Thyroid hormones regulate cell proliferation, differentiation as well as apoptosis. However molecular mechanism underlying apoptosis as a result of thyroid hormone signaling is poorly understood. The antiapoptotic role of Senescence Marker Protein-30 (SMP30) has been characterized in response to varieties
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Protokolle

Online SPE/LC-MS Method for the Rapid Analysis of Thyroid Hormones in Plasma

Determination of the thyroid hormones T4, T3 and rT3 from plasma using an Ascentis Express RP-Amide cartridge to trap the analytes, and a Phenyl-Hexyl column to resolve them.

Online Solid Phase Extraction and LC-MS Analysis of Thyroid Hormones in Human Serum

Thyroid hormones play critical roles in the regulation of biological processes, such as growth, metabolism, protein synthesis, and brain development. For a clinical laboratory, fast and reliable measurements of total hormone levels are important for the diagnosis and monitoring of thyroid diseases.

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