L-032

Lacosamide-¹³C, D₃ solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®

• Empirische Formel (Hill-System): ¹³CC₁₂D₃H₁₅N₂O₃
• Molekulargewicht: 254.30
• UNSPSC-Code: 41116107
• NACRES: NA.24

Eigenschaften

• Qualität: certified reference material
• Qualitätsniveau: 300
• Form: liquid
• Leistungsmerkmale: Snap-N-Spike^®/Snap-N-Shoot^®
• Verpackung: ampule of 1 mL
• Hersteller/Markenname: Cerilliant^®
• Konzentration: 1.0 mg/mL in acetonitrile
• Methode(n): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Anwendung(en): clinical testing
• Format: single component solution
• Lagertemp.: −20°C
• SMILES String: [2H][13C]([2H])([2H])OC[C@@H](NC(C)=O)C(=O)NCc1ccccc1
• InChI: 1S/C13H18N2O3/c1-10(16)15-12(9-18-2)13(17)14-8-11-6-4-3-5-7-11/h3-7,12H,8-9H2,1-2H3,(H,14,17)(H,15,16)/t12-/m1/s1/i2+1D3
• InChIKey: VPPJLAIAVCUEMN-RUXIMPAMSA-N

Beschreibung

Allgemeine Beschreibung

An internal standard suitable for GC/MS or LC/MS applications in lacosamide testing from clinical toxicology and forensic analysis to urine drug testing and isotope dilution methods. Lacosamide is a new antiepileptic drug approved by the FDA in late 2008 for the treatment of partial-onset seizures and diabetic neuropathic pain. The drug is marketed under the trade name Vimpat^®.

Anwendung

• Pharmacokinetic study of lacosamide: A study employed ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) to selectively quantify lacosamide in human plasma. Lacosamide-¹³C, D₃ was utilized as an internal standard to facilitate precise measurement during pharmacokinetic evaluations in healthy subjects, enhancing the understanding of dose-dependent dynamics (Bharwad et al., 2020).

Rechtliche Hinweise

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Vimpat is a registered trademark of Harris FRC Corporation

Sicherheitshinweise

• Piktogramme: GHS02,GHS07
• Signalwort: Danger
• H-Sätze: H225,H302 + H312 + H332,H319
• P-Sätze: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 2
• Flammpunkt (°F): 35.6 °F - closed cup
• Flammpunkt (°C): 2 °C - closed cup