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Merck

E-016

Supelco

Ethyl-β-D-glucuronid

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirische Formel (Hill-System):
C8H14O7
CAS-Nummer:
Molekulargewicht:
222.19
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24

Qualität

certified reference material

Form

liquid

Leistungsmerkmale

Snap-N-Spike®/Snap-N-Shoot®

Verpackung

ampule of 1 mL

Hersteller/Markenname

Cerilliant®

Konzentration

100 μg/mL in methanol

Methode(n)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Anwendung(en)

forensics and toxicology

Format

single component solution

Lagertemp.

−20°C

SMILES String

O[C@H]1[C@H](O)[C@@H](C(O)=O)O[C@@H](OCC)[C@@H]1O

InChI

1S/C8H14O7/c1-2-14-8-5(11)3(9)4(10)6(15-8)7(12)13/h3-6,8-11H,2H2,1H3,(H,12,13)/t3-,4-,5+,6-,8+/m0/s1

InChIKey

IWJBVMJWSPZNJH-UQGZVRACSA-N

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Allgemeine Beschreibung

This Certified Reference Material is widely used in forensic analysis and clinical toxicology applications to determine blood alcohol content.

Ethyl-β-D-glucuronide (EtG) is a water-soluble and stable metabolite of ethanol, used as a routine biomarker in alcohol abuse monitoring. A very small fraction of ethanol undergoes degradation to EtG, and it can be detected in body fluids as well as hair.

Anwendung

The certified reference solution (CRM) in solution can also be used as follows:

  • Multi-residue analysis of different alcohol metabolites in human blood plasma and urine samples by ultra-high performance liquid chromatography (UHPLC) combined with tandem mass spectrometry (MS/MS)
  • Optimization of a supercritical fluid chromatography-tandem mass spectrometric (SFC-MS/MS) method for the separation and quantification of highly polar drugs and their metabolites using an ion-exchange stationary phase from human urine samples
  • Evaluation of a paired ion electrospray ionization mass spectrometric (PIESI-MS) approach coupled with high performance liquid chromatographic (HPLC) procedure for the detection and measurement of drug metabolites in urine samples
  • Assess the impact of sample preparation of hair samples on the quantitative analysis of ethyl-β-D-glucuronide by ultra-high performance liquid chromatography-electrospray ionization-tandem mass spectrometry
  • Analysis of ethyl-β-D-glucuronide as a urinary biomarker in human urine samples by a benchtop gas chromatograph coupled with a mass spectrometer (GC-MS)

Leistungsmerkmale und Vorteile

  • Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
  • Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
  • Rigorously tested through real-time stability studies to ensure accuracy and shelf life
  • Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
  • Flame sealed under argon into ampoules for long-term shelf life
  • Offered in a convenient, DEA-exempt format to improve laboratory efficiency

Rechtliche Hinweise

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Zielorgane

Eyes

Lagerklassenschlüssel

3 - Flammable liquids

WGK

WGK 1

Flammpunkt (°F)

49.5 °F - closed cup

Flammpunkt (°C)

9.7 °C - closed cup


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Sensitive detection of anionic metabolites of drugs by positive ion mode HPLC-PIESI-MS
Guo H, et al.
International Journal of Mass Spectrometry, 389, 14-25 (2015)
A simplified approach for determination of urinary ethyl glucuronide by gas chromatography-mass spectrometry
Ghosh S, et al.
Journal of analytical science and technology, 12, 1-9 (2021)
Jeremy N Matlow et al.
Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharamcologie clinique, 19(3), e473-e482 (2012-11-06)
Ethyl glucuronide (EtG) is arising as a promising biomarker of heavy prenatal alcohol exposure, however its transfer across the human placenta is still unclear and is currently being investigated using the ex vivo placental perfusion model. This model allows for
J N Matlow et al.
Placenta, 34(4), 369-373 (2013-02-05)
Alcohol consumption during pregnancy can lead to Fetal Alcohol Spectrum Disorder (FASD), and because maternal self-reports are often unreliable, biomarkers of alcohol use are sometimes necessary to accurately determine fetal risk. Ethyl glucuronide (EtG), a direct metabolite of ethanol, has
Scott H Stewart et al.
Alcohol and alcoholism (Oxford, Oxfordshire), 48(1), 83-87 (2012-09-28)
Hair ethyl glucuronide (EtG) is a promising biomarker of moderate-to-heavy alcohol consumption and may have utility in detecting and monitoring alcohol use in clinical populations where alcohol use is of particular importance. This study evaluated the relationship between hair EtG

Artikel

Review of clinically relevant ethanol metabolites and analytical method development for the analysis of ethyl glucuronide and ethyl sulfate in urine matrix.

The method shown uses HILIC mode on an Ascentis® Express OH5 column to retain both analytes well, making it very likely to be more robust and reliable, as well as highly MS-friendly.

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.