D-111

N-Desmethylzopiclone solution

100 μg/mL in acetonitrile, certified reference material, Cerilliant^®

• Empirische Formel (Hill-System): C₁₆H₁₅ClN₆O₃
• CAS-Nummer: 59878-63-6
• Molekulargewicht: 374.78
• MDL-Nummer: MFCD08063745
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 329798670
• NACRES: NA.24

Eigenschaften

• Qualität: certified reference material
• Qualitätsniveau: 300
• Form: liquid
• Leistungsmerkmale: Snap-N-Spike^®/Snap-N-Shoot^®
• Verpackung: ampule of 1 mL
• Hersteller/Markenname: Cerilliant^®
• Konzentration: 100 μg/mL in acetonitrile
• Methode(n): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Anwendung(en): clinical testing
• Format: single component solution
• Lagertemp.: −20°C
• SMILES String: ClC(C=N1)=CC=C1N(C2=O)C(OC(N3CCNCC3)=O)C4=C2N=CC=N4
• InChI: 1S/C16H15ClN6O3/c17-10-1-2-11(21-9-10)23-14(24)12-13(20-4-3-19-12)15(23)26-16(25)22-7-5-18-6-8-22/h1-4,9,15,18H,5-8H2
• InChIKey: CGSFZSTXVVJLIX-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A certified Snap-N-Spike^® solution suitable as starting material in calibrators or controls in LC/MS or GC/MS n-desmethylzopiclone testing methods for applications such as urine drug testing, clinical toxicology, or forensic analysis. N-desmethylzopiclone is a primary, inactive metabolite of zopiclone in urine and blood. The parent drug, zopiclone, is a non-benzodiazepine hypnotic used in the treatment of insomnia.

Anwendung

<ul>
<li><strong>Pharmacokinetic study of zopiclone metabolites:</strong> An in-depth examination of pharmacokinetics, focusing on zopiclone and its metabolites, including N-Desmethylzopiclone, to assess their distribution in hair samples post-administration it is used as an additional marker to confirm the intake of zopiclone (Hansen et al., 2020).</li>
<li><strong>Enantioselective analysis after biotransformation:</strong> The study developed a new and rapid method for the enantioselective analysis of N-Desmethylzopiclone, using fungal biotransformation, crucial for understanding metabolic pathways and anxiolytic activity in pharmaceutical research(de Albuquerque et al., 2015).</li>
<li><strong>Validation of analytical methods for forensic application:</strong> A validated LC-MS/MS method for determining zopiclone, N-Desmethylzopiclone, and other related compounds in blood, providing a reliable tool for forensic and clinical toxicology analyses (Nilsson et al., 2015).</li>
<li><strong>Quantitative analysis in urine:</strong> A comprehensive study on the quantitative analysis of zopiclone and its derivatives, including N-Desmethylzopiclone, in urine using LC-MS-MS, supporting drug monitoring and toxicological investigations (Nilsson et al., 2014).</li>
</ul>

Rechtliche Hinweise

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS02,GHS07
• Signalwort: Danger
• H-Sätze: H225,H302 + H312 + H332,H319
• P-Sätze: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 2
• Flammpunkt (°F): 35.6 °F - closed cup
• Flammpunkt (°C): 2.0 °C - closed cup