B-035

Buprenorphin-Glucuronid -Lösung

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Synonym(e): Buprenorphin-3-β-D-Glucuronid -Lösung
• Empirische Formel (Hill-System): C₃₅H₄₉NO₁₀
• CAS-Nummer: 101224-22-0
• Molekulargewicht: 643.76
• EG-Nummer: 200-659-6
• MDL-Nummer: MFCD08275541
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 329773109
• NACRES: NA.24

Eigenschaften

• Qualität: certified reference material
• Qualitätsniveau: 300
• Form: liquid
• Leistungsmerkmale: SNAP-N-SPIKE^®, SNAP-N-SHOOT^®
• Verpackung: ampule of 1 mL
• Hersteller/Markenname: Cerilliant^®
• drug control: Narcotic Licence Schedule A (Switzerland)
• Konzentration: 100 μg/mL in methanol
• Methode(n): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Anwendung(en): clinical testing
• Format: single component solution
• Lagertemp.: −20°C
• SMILES String: CO[C@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]4Cc5ccc(O[C@@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O)C(O)=O)c7O[C@@H]2[C@]3(CCN4CC8CC8)c57
• InChI: 1S/C35H49NO10/c1-31(2,3)32(4,42)20-15-33-10-11-35(20,43-5)30-34(33)12-13-36(16-17-6-7-17)21(33)14-18-8-9-19(26(46-30)22(18)34)44-29-25(39)23(37)24(38)27(45-29)28(40)41/h8-9,17,20-21,23-25,27,29-30,37-39,42H,6-7,10-16H2,1-5H3,(H,40,41)/t20-,21-,23+,24+,25-,27+,29-,30-,32+,33-,34+,35-/m1/s1
• InChIKey: CZULHKGIAJASAA-WWIHBJMFSA-N

Beschreibung

Allgemeine Beschreibung

Buprenorphin-Glucuronid ist ein wesentlicher Harn-Metabolit des halbsynthetischen Opioids Buprenorphin. Diese zertifizierte Dotierlösung^® eignet sich für die Verwendung in LC/MS- oder GC/MS-Anwendungen in der klinischen Toxikologie, forensischen Analytik, Urin-Drogenkontrolle oder Schmerzmittelüberwachung. Buprenorphin wird zur Behandlung von mäßigen chronischen Schmerzen und bei Opioidabhängigkeit verwendet.

Anwendung

• Simplified processing and rapid quantification of buprenorphine, norbuprenorphine, and their conjugated metabolites in human plasma using UPLC-MS/MS: This study underscores the importance of buprenorphine glucuronide as a standard in pharmacokinetic research, facilitating accurate assessments of buprenorphine exposure during opioid use disorder treatment (Zhao et al., 2024).


• Quantitative Analysis of Buprenorphine, Norbuprenorphine, and Their Glucuronide Metabolites in Human Urine: Highlights the application of buprenorphine glucuronide in developing methods for analyzing opioid metabolites in urine, crucial for monitoring drug therapy and compliance in clinical settings (Gqamana et al., 2024).


• Interaction between buprenorphine and norbuprenorphine in neonatal opioid withdrawal syndrome: The research uses buprenorphine glucuronide to study drug interactions in treating neonatal opioid withdrawal, demonstrating its significance in neonatal pharmacological research and therapy optimization (Tobacyk et al., 2023).

Rechtliche Hinweise

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS02,GHS06,GHS08
• Signalwort: Danger
• H-Sätze: H225 - H301 + H311 + H331 - H370
• P-Sätze: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Gefahreneinstufungen: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Zielorgane: Eyes
• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 1
• Flammpunkt (°F): 49.5 °F - closed cup
• Flammpunkt (°C): 9.7 °C - closed cup