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870817P

Avanti

N-palmitoylglycine

Avanti Research™ - A Croda Brand

Synonym(e):

Glycine, N-(1-oxohexadecyl)-

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About This Item

Empirische Formel (Hill-System):
C18H35NO3
CAS-Nummer:
2441-41-0
Molekulargewicht:
313.48
UNSPSC-Code:
12352211
NACRES:
NA.25

Form

powder

Verpackung

pkg of 1 × 10 mg (870817P-10mg)

Hersteller/Markenname

Avanti Research™ - A Croda Brand

Lipid-Typ

neutral glycerides
neutral lipids

Versandbedingung

dry ice

Lagertemp.

−20°C

SMILES String

O=C(CCCCCCCCCCCCCCC)NCC(O)=O

InChI

1S/C18H35NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17(20)19-16-18(21)22/h2-16H2,1H3,(H,19,20)(H,21,22)

InChIKey

KVTFEOAKFFQCCX-UHFFFAOYSA-N

Allgemeine Beschreibung

N-palmitoylglycine belongs to the family of acyl amides, which are endogenous lipids with a potential to modulate pain and inflammation. Structurally, N-palmitoylglycine (PalGly) comprises 16-carbon saturated fatty acid attached to glycine through amide linkage. It is a structural analog of phospholipid-derived N-acyl ethanolamine. N-palmitoylglycine, a saturated lipid is endogenously produced at high levels in rat skin and spinal cord.

Anwendung

N-palmitoylglycine has been used as an intact polar lipid (IPL) standard for determination of δ 15N values of nitrogen containing headgroups of IPLs using gas chromatography/combustion/isotope-ratio mass spectrometry.

Biochem./physiol. Wirkung

N-palmitoylglycine stimulates calcium influx and nitric oxide (NO) production through calcium-sensitive nitric-oxide synthase in sensory neurons. It acts as a lipid activator of G-protein-coupled receptor GPR132.

Verpackung

5 mL Amber Glass Screw Cap Vial (870817P-10mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Cyrine Ezzili et al.
Bioorganic & medicinal chemistry letters, 20(20), 5959-5968 (2010-09-08)
Key studies leading to the discovery and definition of the role of endogenous fatty acid amide signaling molecules are summarized.
Neta Rimmerman et al.
Molecular pharmacology, 74(1), 213-224 (2008-04-22)
N-arachidonoyl glycine is an endogenous arachidonoyl amide that activates the orphan G protein-coupled receptor (GPCR) GPR18 in a pertussis toxin (PTX)-sensitive manner and produces antinociceptive and antiinflammatory effects. It is produced by direct conjugation of arachidonic acid to glycine and
Shalini Chaturvedi et al.
Prostaglandins & other lipid mediators, 81(3-4), 136-149 (2006-11-07)
Oleamide (cis-9-octadecenamide) is a member of an emerging class of lipid-signaling molecules, the primary fatty acid amides. A growing body of evidence indicates that oleamide mediates fundamental neurochemical processes including sleep, thermoregulation, and nociception. Nevertheless, the mechanism for oleamide biosynthesis
James R Foster et al.
Pharmacology research & perspectives, 7(6), e00542-e00542 (2019-11-27)
The G-protein-coupled receptor GPR132, also known as G2A, is activated by 9-hydroxyoctadecadienoic acid (9-HODE) and other oxidized fatty acids. Other suggested GPR132 agonists including lysophosphatidylcholine (LPC) have not been readily reproduced. Here, we identify N-acylamides in particular N-acylglycines, as lipid
Heather B Bradshaw et al.
Vitamins and hormones, 81, 191-205 (2009-08-04)
Discovery of the endogenous cannabinoid and N-acyl amide, anandamide (N-arachidonoyl ethanolamine), paved the way for lipidomics discoveries in the growing family of N-acyl amides. Lipidomics is a field that is broadening our view of the molecular world to include a
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