860654P

sphinganine (d17:0)

Avanti Research^™ - A Croda Brand 860654P, powder

• Synonym(e): D-erythro-sphinganine (C17 base)
• Empirische Formel (Hill-System): C₁₇H₃₇NO₂
• CAS-Nummer: 32164-02-6
• Molekulargewicht: 287.48
• UNSPSC-Code: 12352211
• NACRES: NA.25

Eigenschaften

• Form: powder
• Verpackung: pkg of 1 × 10 mg (860654P-10mg); pkg of 1 × 5 mg (860654P-5mg)
• Hersteller/Markenname: Avanti Research^™ - A Croda Brand 860654P
• Lipid-Typ: sphingolipids
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: OC[C@@](N)([H])[C@]([H])(O)CCCCCCCCCCCCCC
• InChI: 1S/C17H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(20)16(18)15-19/h16-17,19-20H,2-15,18H2,1H3/t16-,17+/m0/s1
• InChIKey: KFQUQCFJDMSIJF-DLBZAZTESA-N

Beschreibung

Allgemeine Beschreibung

Sphinganine (d17:0), also referred to as dihydrosphingosine, is devoid of double bond. Decarboxylating condensation of serine with palmitoyl-CoA yield keto intermediate(2-oxosphinganine), which is then reduced by NADPH to form Sphinganine.

Anwendung

Sphinganine (d17:0) has been used in liquid chromatography-mass spectrometry (LC-MS) for the in-situ estimation of dihydrosphingosine utilization in N-(4-hydroxyphenyl)retinamide (4-HPR) resistant leukemia cells. It is suitable for use as an internal standard in metabolomic study.

Biochem./physiol. Wirkung

Sphinganine (SPA) or D-erythro-sphinganine is involved in sphingolipid biosynthesis pathway. It acts as a precursor for ceramide. SPA has an ability to inhibit the activity of protein kinase c. SPA accumulation enables fumonisin B1 to stimulate apoptosis. It also has an ability to block cholesterol transport in Niemann-Pick Type C (NPC) disease.

Verpackung

5 mL Amber Glass Screw Cap Vial (860654P-10mg)

5 mL Amber Glass Screw Cap Vial (860654P-5mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3