860058P

Ganglioside GM3 (Bovine Milk)

Avanti Research^™ - A Croda Brand

• Synonym(e): 110953
• CAS-Nummer: 1246353-19-4
• UNSPSC-Code: 12352211
• NACRES: NA.25

Eigenschaften

• Beschreibung: GM3 Ganglioside (Milk, Bovine-Ammonium Salt)
• Assay: >99% (TLC)
• Form: powder
• Verpackung: pkg of 1 × 1 mg (860058P-1mg); pkg of 1 × 10 mg (860058P-10mg); pkg of 1 × 25 mg (860058P-25mg); pkg of 1 × 5 mg (860058P-5mg)
• Hersteller/Markenname: Avanti Research^™ - A Croda Brand
• Lipid-Typ: sphingolipids
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: [H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCCC)=O)CO[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@@H]([C@H](O[C@@]3(C([O-])=O)O[C@@H]([C@H](O)[C@H](O)CO)[C@@](NC(C)=O)([H])[C@@H](O)C3)[C@H]2O)O)[C@@H](CO)O1.[NH4+]

Beschreibung

Allgemeine Beschreibung

Ganglioside monosialodihexosylganglioside (GM3) are glycosphingolipids (GSLs), which are membrane-bound consisting of a sialic acid residue and an oligosaccharide head structure. It is found in milk and kidney cells. GM3 is the most broadly distributed ganglioside in tissues.

Anwendung

Ganglioside GM3 (Bovine Milk) has been used in lipid binding assay to assess the binding of monoclonal antibodies (mAbs). It may be used as a standard to investigate the efficiency of ganglioside extraction in brain using electrospray ionization-mass spectrometry (ESI MS) analysis. It may also be used for the structural characterization of gangliosides using ultraviolet photodissociation mass spectrometry.

Biochem./physiol. Wirkung

Ganglioside monosialodihexosylganglioside (GM3) blocks the activity of fibroblast growth factor receptor. GM3-enriched microdomain is involved in modulating cell growth. Low levels of ganglioside GM3 is involved in the pathogenesis of rheumatoid arthritis. GM3 regulates immunological functions by preventing cytokine production. It regulates apoptosis, cell proliferation and differentiation. GM3 is also involved in cellular signaling pathways, cell adhesion and mobility. Increased GM3 levels are associated with diabetic nephropathy.

Verpackung

5 mL Amber Glass Screw Cap Vial (860058P-10mg)

5 mL Amber Glass Screw Cap Vial (860058P-1mg)

5 mL Amber Glass Screw Cap Vial (860058P-25mg)

5 mL Amber Glass Screw Cap Vial (860058P-5mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids