857371P
Avanti
VU0359595
(1R,2R)-N-([S]-1-{4-[5-bromo-2-oxo-2,3-dihydro-1H-benzo(d)imidazol-1-yl]piperidin-1-yl}propan-2-yl)-2-phenylcyclopropanecarboxamide, powder
Synonym(e):
EVJ; VU0359595
Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(4)
About This Item
Empirische Formel (Hill-System):
C25H29BrN4O2
CAS-Nummer:
Molekulargewicht:
497.43
UNSPSC-Code:
12352211
NACRES:
NA.25
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Assay
>99% (TLC)
Form
powder
Verpackung
pkg of 1 × 1 mg (857371P-1mg)
Hersteller/Markenname
Avanti Research™ - A Croda Brand 857371P
Lipid-Typ
bioactive lipids
Versandbedingung
dry ice
Lagertemp.
−20°C
Allgemeine Beschreibung
VU0359595 has been shown to selectively inhibit the PLD1 isoform at nM levels (see data below). **Images added as .gif in folder
Anwendung
VU0359595 has been used as PLD2 (phospholipase D2) inhibitor to quantitatively address functional and molecular aspects of the involvement of PLD-derived phosphatidic acid (PA) in regulated exocytosis and as PLD1 inhibitor to treat the knockout mice to study its effects on them.
Biochem./physiol. Wirkung
VU0359595 helps to block phospholipase D (PLD) which in turn reduces deoxyribonucleoside triphosphate (dNTP) biosynthesis in glioma models.
Verpackung
5 mL Amber Glass Screw Cap Vial (857371P-1mg)
Rechtliche Hinweise
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
The role of phospholipase D in regulated exocytosis
Rogasevskaia TP and Coorssen JR
The Journal of biological chemistry, 290(48), 28683-28696 (2015)
Human phospholipase D activity transiently regulates pyrimidine biosynthesis in malignant gliomas
Mathews TP, et al.
ACS Chemical Biology, 10(5), 1258-1268 (2015)
Jana A Lewis et al.
Bioorganic & medicinal chemistry letters, 19(7), 1916-1920 (2009-03-10)
This Letter describes the synthesis and structure-activity-relationships (SAR) of isoform-selective PLD inhibitors. By virtue of the installation of alternative halogenated piperidinyl benzimidazolone privileged structures, in combination with a key (S)-methyl group, novel PLD inhibitors with low nM potency and unprecedented
Binding of PLD2-generated phosphatidic acid to KIF5B promotes MT1-MMP surface trafficking and lung metastasis of mouse breast cancer cells
Wang Z, et al.
Developmental Cell, 43(2), 186-197 (2017)
Xianping Li et al.
Infection and immunity, 80(1), 429-440 (2011-11-16)
Aspergillus fumigatus is the most prevalent airborne fungal pathogen that induces serious infections in immunocompromised patients. Phospholipases are key enzymes in pathogenic fungi that cleave host phospholipids, resulting in membrane destabilization and host cell penetration. However, knowledge of the impact
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