810184P

TopFluor^™ PI(4,5)P2

Avanti Research^™ - A Croda Brand 810184P, powder

• Synonym(e): 1-oleoyl-2-{6-[4-(dipyrrometheneboron difluoride)butanoyl]amino}hexanoyl-sn-glycero-3-phosphoinositol-4,5-bisphosphate (ammonium salt)
• Empirische Formel (Hill-System): C₅₀H₇₈BF₂N₃O₂₀P₃
• CAS-Nummer: 1246355-57-6
• Molekulargewicht: 1182.89
• MDL-Nummer: MFCD00036835
• UNSPSC-Code: 12352211
• NACRES: NA.25

Eigenschaften

• Assay: >99% (TLC)
• Form: powder
• Verpackung: pkg of 1 × 50 μg (with stopper and crimp cap (810184P-50ug))
• Hersteller/Markenname: Avanti Research^™ - A Croda Brand 810184P
• Versandbedingung: dry ice
• Lagertemp.: −20°C

Beschreibung

Allgemeine Beschreibung

Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT.

Anwendung

TopFluor^™ PI(4,5)P2 or 1-oleoyl-2-{6-[4-(dipyrrometheneboron difluoride)butanoyl]amino}hexanoyl-sn-glycero-3-phosphoinositol-4,5-bisphosphate (ammonium salt) has been used as a fluorescent lipid in living cells to analyse the cellular localization of phosphatidylinositol (PI) and in the preparation of giant unilamellar vesicles (GUVs) for the ezrin-membrane tethering assays.

Verpackung

2 mL Amber Serum Vial with Stopper and Crimp Cap (810184P-50ug)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

TopFluor is a trademark of Avanti Polar Lipids, LLC

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): No data available
• Flammpunkt (°C): No data available