700081P

7β,25-dihydroxycholesterol

Avanti Polar Lipids

• Synonym(e): cholest-5-ene-3β,7β,25-triol
• Empirische Formel (Hill-System): C₂₇H₄₆O₃
• CAS-Nummer: 64907-21-7
• Molekulargewicht: 418.65
• UNSPSC-Code: 12352211
• NACRES: NA.25

Eigenschaften

• Form: powder
• Verpackung: pkg of 1 × 1 mg (700081P-1mg)
• Hersteller/Markenname: Avanti Polar Lipids
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: CC1(CC[C@H](O)C2)C2=C[C@H](O)C3C1CCC4(C)C3CCC4C(CCCC(C)(O)C)C

Beschreibung

Allgemeine Beschreibung

7β,25-dihydroxycholesterol (7β25OHC) is an isomer of 7α,25-dihydroxycholesterol (7α25OHC). Its synthesis from 7-keto,25-hydroxycholesterol (7k25OHC) is catalyzed by 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1). 11β-Hydroxysteroid dehydrogenase type 2 (11β-HSD2) catalyzes the reverse oxidation from 7β25OHC to 7k25OHC.

Anwendung

7β,25-dihydroxycholesterol has been used as a substrate for 11β-Hydroxysteroid dehydrogenase (11β-HSD)-dependent metabolic studies of oxysterols in human embryonic kidney (HEK-293) cells in enzyme kinetics assay and as a standard in high-performance liquid chromatography(HPLC) for detection of dihydroxycholesterols in human plasma.

Biochem./physiol. Wirkung

7β,25-dihydroxycholesterol is an Epstein-Barr virus-induced gene 2 (EBI2) ligand and is comparatively a weaker chemoattractant than 7α,25-dihydroxycholesterol (7α25OHC).

Verpackung

5 mL Amber Glass Screw Cap Vial (700081P-1mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids