QBD10194

NHS-S-S-dPEG^®₄-biotin (cleavable)

• Synonym(e): 2,5-Dioxo-1-pyrrolidinyl 29-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-9,25-dioxo-12,15,18,21-tetraoxa-4,5-dithia-8,24-diazanonacosanoate, Polyethylene glycol
• Empirische Formel (Hill-System): C₃₀H₄₉N₅O₁₁S₃
• CAS-Nummer: 1260247-51-5
• Molekulargewicht: 751.93
• UNSPSC-Code: 51171641
• PubChem Substanz-ID: 329823886
• NACRES: NA.22

Eigenschaften

• Assay: >90%
• Form: solid or viscous liquid
• Eignung der Reaktion: reaction type: Biotinylations; reagent type: cross-linking reagent
• Funktionelle Gruppe: disulfide
• Polymerarchitektur: shape: linear; functionality: monofunctional
• Versandbedingung: ambient
• Lagertemp.: −20°C
• SMILES String: O=C(NCCSSCCC(ON1C(CCC1=O)=O)=O)CCOCCOCCOCCOCCNC(CCCCC2C3NC(NC3CS2)=O)=O

Beschreibung

Leistungsmerkmale und Vorteile

NHS-S-S-dPEG^®₄-biotin is used extensively to label molecules that contain a free amine with biotin. This dPEG^® spacer imparts a high degree of water solubility to the biotin label. For biotinylated peptides and proteins, the dPEG^® spacer dramatically reduces aggregation and precipitation of the modified molecule and reduces non-specific binding of the molecule, both of which are common problems with molecules that have been biotinylated with the widely used NHS-LC-biotin. NHS-S-S-dPEG^®₄-biotin contains a disulfide group in the linear chain, allowing the biotin to be cleaved reductively from the labeled molecule.

Rechtliche Hinweise

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable