N3633

β-Naphthoflavon

≥98%

• Synonym(e): 5,6-Benzoflavon
• Empirische Formel (Hill-System): C₁₉H₁₂O₂
• CAS-Nummer: 6051-87-2
• Molekulargewicht: 272.30
• Beilstein: 18991
• EG-Nummer: 227-958-4
• MDL-Nummer: MFCD00004986
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 57654450
• NACRES: NA.22

Eigenschaften

• Assay: ≥98%
• Farbe: off-white to yellow
• mp (Schmelzpunkt): 164-166 °C (lit.)
• Lagertemp.: 2-8°C
• SMILES String: O=C1C=C(Oc2ccc3ccccc3c12)c4ccccc4
• InChI: 1S/C19H12O2/c20-16-12-18(14-7-2-1-3-8-14)21-17-11-10-13-6-4-5-9-15(13)19(16)17/h1-12H
• InChIKey: OUGIDAPQYNCXRA-UHFFFAOYSA-N
• Angaben zum Gen: rat ... Gabra2(29706)

Beschreibung

Allgemeine Beschreibung

β-Naphthoflavone is a polyaromatic hydrocarbon.

Anwendung

β-Naphthoflavone has been used:

• as aryl hydrocarbon receptor agonist to elucidate its effect on Cyp1A1 expression in embryos of transgenic cytochrome P450 1A1 (cyp1a) reporter zebrafish
• as AhR agonists, to treat primary normal human epidermal keratinocytes (NHEKs) to study about aryl hydrocarbon receptor (AhR) activation by western blot analysis
• to determine its effect on the expression of dystrophin (Dp)71
• to stimulate the expression of causes recombination (Cre) recombinase and to delete the flanking alleles of locus of crossing (x) over, P1 (loxP) sequences

Biochem./physiol. Wirkung

β-Naphthoflavone (BNF) is an exogenous ligand for aryl hydrocarbon receptor (AhR) in humans. It is an inducer of phase I detoxification enzymes (CYPs) and phase II enzymes (UDP-GTs) and NAD(P)H-dependent quinone oxyreductase-1(NQO1). It also induces cytochrome P450 (Cyp1a). BNF represses the expression of Duchenne muscular dystrophy gene, dystrophin (Dp)71 by altering the binding of the transcription factors.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves