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Sigma-Aldrich

N-(2-Hydroxy) propyl-3-trimethylammonium chitosan chloride

degree of quaternization 50%

Synonym(e):

Chioisan, HTCC, Quaternized Chitosan, Solube chitosan, TMC, Trimethyl chitoan

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About This Item

Lineare Formel:
(C12H25N2O5Cl)n(C8H13NO5)m
UNSPSC-Code:
12352201

Beschreibung

NMR: Conforms to structure

Qualitätsniveau

100

Form

(solid, chunks or fiber)

Farbe

white to off-white

Lagertemp.

2-8°C

Verwandte Kategorien

Allgemeine Beschreibung

Chitosan offers remarkable biological properties; it has been widely used in drug delivery and tissue engineering applications. Chitosan has good mucoadhesive properties due to its positive charge, which increases the adhesion to mucosa and facilitates drug penetration. Also, chitosan possesses hemostatic properties, which makes it a good candidate for wound dressing applications.

The quaternization of the primary amine increases the water solubility of chitosan and keeps chitosan soluble over a wide pH range. Cationically modified chitosan such as N-(2-Hydroxy)propyl-3-trimethyl ammonium chitosan chloride (HTCC) also imparts excellent antibacterial activity and immuno-enhancing characteristics. HTCC also used in gene delivery applications

Anwendung

Small molecule and nucleic acid delivery
Tissue engineering
Antibacterial coatings

Leistungsmerkmale und Vorteile

Water soluble
Cationically modified
Naturally derived and biocompatible

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Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Bo Xiao et al.
Colloids and surfaces. B, Biointerfaces, 91, 168-174 (2011-11-23)
A series of N-(2-hydroxy)propyl-3-trimethyl ammonium chitosan chloride (HTCC) samples with various degrees of quaternization ranging from 12.4 to 43.7% was synthesized. The structures and properties of HTCC were investigated by FT-IR, (1)H NMR, conductometric titration and XRD analysis. It was
Hamid Hamedi et al.
Carbohydrate polymers, 199, 445-460 (2018-08-26)
Advanced development of chitosan hydrogels has led to new drug delivery systems that can release their active ingredients in response to environmental stimuli. This review considers more recent investigation of chitosan hydrogel preparations and the application of these preparations for

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