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Merck

933570

Sigma-Aldrich

NanoFabTx- Maleimide Lipid Mix

for synthesis of maleimide-functionalized liposomes

Synonym(e):

Cholesterol, DSPC-PEG-Maleimide, HSPC

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About This Item

UNSPSC-Code:
12352211
NACRES:
NA.21

Qualitätsniveau

Lagertemp.

−20°C

Anwendung

NanoFabTx Maleimide Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of maleimide-functionalized liposomes. Maleimide is a stable and easy-to-handle moiety that rapidly and covalently conjugates thiol groups of cysteine residues in proteins or peptides. This lipid mix enables users to encapsulate a wide variety of small molecules for targeting and immunotherapy applications without the need for lengthy trial-and-error optimization.
This product includes a curated lyophilized lipid mixture containing rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of liposomes. Step-by-step protocols for the synthesis of liposomes surface-functionalized with maleimide groups using extrusion and microfluidics are also included. The synthesized maleimide-functionalized liposomes enable facile conjugation of targeting groups like proteins, peptides, and other thiol-containing moieties onto the liposome surface for targeted drug delivery.

Leistungsmerkmale und Vorteile

  • A ready-to-use nanoformulation lipid blend for the synthesis of maleimide-functionalized liposomes
  • Step-by-step protocols developed and tested by our formulation scientists
  • Flexible synthesis tool to create uniform and reproducible liposomes
  • Maleimide surface functionalization allows for targeting ligand and protein conjugation to enable targeted drug delivery
Comprehensive protocols for liposome synthesis are included:

  • A lipid film hydration and extrusion protocol
  • A microfluidics protocol using commercial platforms or syringe pumps
The microfluidics protocol included with this product uses the NanoFabTx device kit (911593). These kits come with the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

Rechtliche Hinweise

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3


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Die Dokumentenbibliothek aufrufen

Hanmei Li et al.
Journal of biomedical nanotechnology, 17(12), 2382-2390 (2022-01-04)
Albumin, the most abundant protein in plasma, has been widely used in drug delivery studies. Here, we developed maleimide-functionalized liposomes (Mal-Lip) that can bind to endogenous albumin to improve the tumor targeting efficiency of liposomes. Transmission electron microscopy and gel
Mira Oswald et al.
International journal of pharmaceutics, 514(1), 93-102 (2016-11-20)
Numerous examples exist in the literature for the use of maleimide-thiol-reactions in the area of functionalized nanoparticles. Although the hydrolysis tendency of maleimides is well-known, qualitative and quantitative information on the stability and reactivity of maleimide groups during preparation and
Tianshu Li et al.
International journal of nanomedicine, 9, 2849-2861 (2014-06-19)
With a small amount of maleimide modification on the liposome surface, enhanced cellular uptake of liposomes and drug-delivery efficiency can be obtained both in vitro and in vivo. Herein, we describe the mechanisms underlying this enhanced cellular uptake. Suppression of

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