927678

Pomalidomide-difluoroPEG₁-C₄-piperazine Hydrochloride

≥95%

• Synonym(e): 2-(2,2-Difluoro-3-(4-(piperazin-1-yl)butoxy)propoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide hydrochloride
• Empirische Formel (Hill-System): C₂₆H₃₃F₂N₅O₇ · xHCl
• Molekulargewicht: 565.57 (free base basis)
• MDL-Nummer: MFCD34622467
• UNSPSC-Code: 12352101
• NACRES: NA.21

Eigenschaften

• ligand: pomalidomide
• Qualitätsniveau: 100
• Assay: ≥95%
• Form: powder
• Lagertemp.: 2-8°C
• SMILES String: O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCC(F)(F)COCCCCN4CCNCC4)=O)=O)NC1=O.Cl
• InChI: 1S/C26H33F2N5O7.ClH/c27-26(28,15-39-13-2-1-10-32-11-8-29-9-12-32)16-40-14-21(35)30-18-5-3-4-17-22(18)25(38)33(24(17)37)19-6-7-20(34)31-23(19)36;/h3-5,19,29H,1-2,6-16H2,(H,30,35)(H,31,34,36);1H
• InChIKey: VNTZNMLSYIMLPL-UHFFFAOYSA-N

Beschreibung

Anwendung

Protein degrader building block Pomalidomide-difluoroPEG₁-C₄-piperazine Hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a fluorinated linker with both hydrophobic and hydrophilic moieties, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Targeted Protein Degradation

Sonstige Hinweise

Impact of linker length on the activity of PROTACs

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation by Small Molecules

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• H-Sätze: H360D
• P-Sätze: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Gefahreneinstufungen: Repr. 1B
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable