925136

4,6-Dimethyl-2-(methylsulfinyl)-3-nitropyridine

• Synonym(e): 2-Sulfonylpyridine, Cysteine-reactive electrophile, S_NAr probe
• Empirische Formel (Hill-System): C₈H₁₀N₂O₃S
• CAS-Nummer: 2429964-95-2
• Molekulargewicht: 214.24
• NACRES: NA.22

Eigenschaften

• Eignung der Reaktion: reagent type: chemical modification reagent
• Qualitätsniveau: 100
• Lagertemp.: 2-8°C

Beschreibung

Anwendung

4,6-Dimethyl-2-(methylsulfinyl)-3-nitropyridine is a sulfoxide-containing fragment for covalent ligand discovery via cysteine labeling as demonstrated by Zamboldo and coworkers. Fragment electrophiles are useful in chemoproteomic and ligandability studies for both traditionally druggable proteins as well as ″undruggable,″ or difficult-to-target, proteins.

Related useful products may include cysteine fragment KB02 (912131), IA alkyne (924237), IA 5-TAMRA (925020), desthiobiotin iodoacetamide (923826), or biotin iodoacetamide (B2059).

Sonstige Hinweise

2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable