902667

Propargyl-PEG6-acid

• Synonym(e): 4,7,10,13,16,19-Hexaoxadocos-21-ynoic acid, Propargyl-PEG6-CH2CO2H
• Empirische Formel (Hill-System): C₁₆H₂₈O₈
• CAS-Nummer: 1951438-84-8
• Molekulargewicht: 348.39
• MDL-Nummer: MFCD28950778
• UNSPSC-Code: 12352106
• NACRES: NA.22

Eigenschaften

• Assay: ≥95%
• Form: liquid
• Eignung der Reaktion: reaction type: click chemistry; reagent type: cross-linking reagent
• Brechungsindex: n/D 1.469
• Funktionelle Gruppe: alkyne; carboxylic acid
• Lagertemp.: −20°C
• SMILES String: OC(CCOCCOCCOCCOCCOCCOCC#C)=O

Beschreibung

Anwendung

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophilic PEG linker facilitates solubility in biological applications. Propargyl-PEG6-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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Rechtliche Hinweise

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable