900756

SLAP M

≥95%

• Synonym(e): 2-((Trimethylsilyl)methoxy)ethan-1-amine
• Empirische Formel (Hill-System): C₆H₁₇NOSi
• CAS-Nummer: 2093935-94-3
• Molekulargewicht: 147.29
• UNSPSC-Code: 12352200

Eigenschaften

• Assay: ≥95%
• Form: liquid
• Lagertemp.: 2-8°C
• SMILES String: NCCOC[Si](C)(C)C

Beschreibung

Anwendung

When used with aliphatic or aromatic aldehydes, this silicon amine protocol (SLAP) reagent enables the photomediated synthesis of thiomorpholines and thiazepanes. For photocatalytic cross-coupling with this SLAP Reagent, Ir[(ppy)₂dtbbpy]PF6 (747769) is used with a recommended starting combination of Lewis acids Bi(OTf)₃ (633305) and Cu(OTf)₂ (283673) prior to subsequent substrate-specific optimization. This product was introduced in collaboration with the Bode Research Group and provides a tin-free alternative to SnAP (tin amine protocol) reagents and is well-suited for scale-up reactions.

Sonstige Hinweise

• Lewis Acid Induced Toggle from Ir(II) to Ir(IV) Pathways in Photocatalytic Reactions: Synthesis of Thiomorpholines and Thiazepanes from Aldehydes and SLAP Reagents
• Silicon Amine Reagents for the Photocatalytic Synthesis of Piperazines from Aldehydes and Ketones

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable