674656

(R)-Tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborol -Lösung

1 M in THF

• Synonym(e): α,α-Diphenyl-D-prolinolmethylboronsäure-cyclamidester, (R)-(+)-2-Methyl-CBS-oxazaborlidin, (R)-1-Methyl,3,3-diphenyl-tetrahydro-pyrrolo-(1,2-c)(1,3,2)-oxazaborol
• Empirische Formel (Hill-System): C₁₈H₂₀BNO
• CAS-Nummer: 112022-83-0
• Molekulargewicht: 277.17
• MDL-Nummer: MFCD00078440
• UNSPSC-Code: 12352005
• PubChem Substanz-ID: 24885228
• NACRES: NA.22

Eigenschaften

• Optische Aktivität: [α]22/D +76.8°, c = 1 in toluene
• Qualitätsniveau: 100
• Konzentration: 1 M in THF
• Brechungsindex: n20/D 1.4602
• Dichte: 0.942 g/mL at 25 °C
• Funktionelle Gruppe: phenyl
• SMILES String: [H][C@]12CCCN1B(C)OC2(c3ccccc3)c4ccccc4
• InChI: 1S/C18H20BNO/c1-19-20-14-8-13-17(20)18(21-19,15-9-4-2-5-10-15)16-11-6-3-7-12-16/h2-7,9-12,17H,8,13-14H2,1H3/t17-/m1/s1
• InChIKey: VMKAFJQFKBASMU-QGZVFWFLSA-N

Beschreibung

Anwendung

CBS-Katalysatoren zur asymmetrischen Reduktion und asymmetrischen Synthese

The CBS (Corey-Bakshi-Shibata) oxazaborolidine catalyst has been used in the asymmetric reduction of prochiral ketones. Other applications include the enantioselective synthesis of α-hydroxy acids, α-amino acids, C₂ symmetrical ferrocenyl diols, and propargyl alcohols.

Sicherheitshinweise

• Piktogramme: GHS02,GHS08,GHS05,GHS07
• Signalwort: Danger
• H-Sätze: H225,H302,H318,H335,H336,H351
• P-Sätze: P202 - P210 - P280 - P301 + P312 - P305 + P351 + P338 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - STOT SE 3
• Zielorgane: Central nervous system, Respiratory system
• Zusätzliche Gefahrenhinweise: EUH019
• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 3
• Flammpunkt (°F): 1.4 °F - closed cup
• Flammpunkt (°C): -17 °C - closed cup
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter