479179

(S)-(−)-4-Hydroxy-2-pyrrolidinon

97%

• Synonym(e): (S)-β-Hydroxy-γ-butyrolactam
• Empirische Formel (Hill-System): C₄H₇NO₂
• CAS-Nummer: 68108-18-9
• Molekulargewicht: 101.10
• Beilstein: 1524192
• MDL-Nummer: MFCD00273370
• UNSPSC-Code: 12352005
• PubChem Substanz-ID: 24871604
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 100
• Assay: 97%
• Optische Aktivität: [α]23/D −43°, c = 1 in ethanol
• mp (Schmelzpunkt): 156-159 °C (lit.)
• Funktionelle Gruppe: hydroxyl
• SMILES String: O[C@@H]1CNC(=O)C1
• InChI: 1S/C4H7NO2/c6-3-1-4(7)5-2-3/h3,6H,1-2H2,(H,5,7)/t3-/m0/s1
• InChIKey: IOGISYQVOGVIEU-VKHMYHEASA-N

Beschreibung

Allgemeine Beschreibung

4-Hydroxy-2-pyrrolidinone is an important building block found in many bioactive compounds like streptopyrrolidine. It can be used as an intermediate in the synthesis of various γ-amino acids (GABA) and substituted 2-pyrrolidinones like cynometrine and cynodine.

Anwendung

(S)-(−)-4-Hydroxy-2-pyrrolidinone can be used as a starting material in the preparation of:

• Biologically significant pyrrolo[1,2:1′,2′]azepino[5,6-b]indole derivatives.
• Substituted azepanes by reacting with various aldehydes via photochemical [5+2] cycloaddition.

Sicherheitshinweise

• Piktogramme: GHS05,GHS07
• Signalwort: Danger
• H-Sätze: H302,H318
• P-Sätze: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Dam. 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)