476994

5-Bromisatin

technical grade, 90%

• Empirische Formel (Hill-System): C₈H₄BrNO₂
• CAS-Nummer: 87-48-9
• Molekulargewicht: 226.03
• Beilstein: 383760
• EG-Nummer: 201-747-7
• MDL-Nummer: MFCD00005719
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24871320
• NACRES: NA.22

Eigenschaften

• Qualität: technical grade
• Assay: 90%
• Verunreinigungen: <10% isatin
• mp (Schmelzpunkt): 247-252 °C (lit.)
• SMILES String: Brc1ccc2NC(=O)C(=O)c2c1
• InChI: 1S/C8H4BrNO2/c9-4-1-2-6-5(3-4)7(11)8(12)10-6/h1-3H,(H,10,11,12)
• InChIKey: MBVCESWADCIXJN-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

5-Bromoisatin is a 5-haloisatin. One of the methods reported for its synthesis is by reacting N-halosaccharins with isatin in the presence of SiO₂. Its inotropic activity has been studied on rhythmically stimulated papillary muscles of guinea pigs. It is reported to exhibit analgesic and sedative properties at a dose of 0.2g/kg in mice.

Anwendung

5-Bromoisatin may be used in the synthesis of the following:

• N-derivatives of 5-bromoisatin
• N-substituted pyrroles
• linear polyaryleneoxindoles
• 5-bromodioxindole
• cinchoninic acid derivatives
• 3-hydroxyoxindole
• S-benzyldithiocarbazate Schiff Bases
• 5-bromooxindole
• Morita-Baylis-Hillman adducts of isatin derivatives

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves