- Nickel-catalyzed Negishi cross-couplings of 6-chloropurines with organozinc halides at room temperature.
Nickel-catalyzed Negishi cross-couplings of 6-chloropurines with organozinc halides at room temperature.
Organic & biomolecular chemistry (2011-09-22)
Dong-Chao Wang, Hong-Ying Niu, Gui-Rong Qu, Lei Liang, Xue-Jiao Wei, Yang Zhang, Hai-Ming Guo
PMID21935566
RÉSUMÉ
An efficient method for the synthesis of 6-alkyl or 6-aryl purines (nucleosides) was developed via nickel-catalyzed Negishi cross-couplings of 6-chloropurines and organozinc halides. The ligand-free process gave good to excellent isolated yields at room temperature.