15019AST

Astec^® CHIROBIOTIC^® V2 Chiral (5 μm) HPLC Columns

L × I.D. 15 cm × 2.1 mm, HPLC Column

• Synonyme(s) : Chiral Stationary Phase Column V2
• Code UNSPSC : 41115700
• eCl@ss : 32110501
• Nomenclature NACRES : SB.52

Propriétés

• product name: Astec^® Chirobiotic^® V2 Chiral HPLC Column, 5 μm particle size, L × I.D. 15 cm × 2.1 mm
• Matériaux: stainless steel column
• Agence: suitable for USP L88
• Description: HPLC column
• Gamme de produits: Astec^®
• Conditionnement: pkg of 1 ea
• Fabricant/nom de marque: Astec^®
• Paramètres: 0-45 °C temperature; 241 bar pressure (3500 psi)
• Technique(s): HPLC: suitable; LC/MS: suitable
• L × D.I.: 15 cm × 2.1 mm
• Matrice: High-purity silica gel particle platform; fully porous particle
• Groupe de la matrice active: vancomycin phase
• Taille des particules: 5 μm
• Dimension de pores: 200 Å
• operating pH range: 3.5-7.0
• Technique de séparation: chiral

Description

Description générale

Neutral molecules, amides, acids, esters and amines show considerable enantioselectivity on these vancomycin-based CSPs. A wide variety of secondary and tertiary amines have been separated on the CHIROBIOTIC^® V in the polar ionic mode. The CHIROBIOTIC^® V has demonstrated many of the separation characteristics of protein-based stationary phases, but with exceptional stability and much higher sample capacity. Some chiral analytes have been resolved that have not been reported separated on any other chiral stationary phase. CHIROBIOTIC^® V and V2 differ in their bonding chemistry the pore size of the support particle, giving them different selectivity and preparative capacity.

• Bonded phase: Vancomycin
• Operating pH range: 3.5 - 7.0
• Particle diameter: 5, 10 or 16 μm
• Pore size: 100 Å (CHIROBIOTIC^® V) or 200 Å (CHIROBIOTIC^® V2)

CHIROBIOTIC FAQs
CHIROBIOTIC Reference Bibliography
Chiral Product Literature

Application

• Development and validation of an UFLC-MS/MS method for enantioselectivity determination of d,l-thero-methylphenidate, d,l-thero-ethylphenidate and d,l-thero-ritalinic acid in rat plasma and its application to pharmacokinetic study.: This study highlights the application of the Astec^® CHIROBIOTIC^® V2 chiral HPLC column in the pharmacokinetic assessment of chiral drugs, demonstrating its utility in accurate and efficient chiral separation for analytical chemistry in pharmacological research (Zhang et al., 2016).



• New high-performance liquid chromatography method for the determination of (R)-warfarin and (S)-warfarin using chiral separation on a glycopeptide-based stationary phase.: This paper describes a method using the Astec^® CHIROBIOTIC^® V2 chiral HPLC column to differentiate between the enantiomers of warfarin, showcasing its critical role in therapeutic drug monitoring and clinical pharmacology, which is essential for ensuring patient safety and efficacy in treatments (Malakova et al., 2009).

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Informations légales

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany

CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC