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X3629

Sigma-Aldrich

X80

≥98% (HPLC)

Synonyme(s) :

5-(5-{[1-(3-carboxyphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]methyl}-2-furyl)-2-chlorobenzoic acid

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About This Item

Formule empirique (notation de Hill):
C23H15ClN2O6
Numéro CAS:
292065-64-6
Poids moléculaire :
450.83
Numéro MDL:
MFCD02086439
Code UNSPSC :
12352200
ID de substance PubChem :
329830804
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

powder

Couleur

orange

Solubilité

DMSO: >40 mg/mL

Température de stockage

2-8°C

Chaîne SMILES 

CC1=NN(c2cccc(c2)C(O)=O)C(=O)\C1=C/c3ccc(o3)-c4ccc(Cl)c(c4)C(O)=O

InChI

1S/C23H15ClN2O6/c1-12-17(21(27)26(25-12)15-4-2-3-14(9-15)22(28)29)11-16-6-8-20(32-16)13-5-7-19(24)18(10-13)23(30)31/h2-11H,1H3,(H,28,29)(H,30,31)/b17-11-

Clé InChI

XZRBYOCWWJMJRZ-BOPFTXTBSA-N

Application

X80 has been used as an inhibitor of nucleotide excision repair (NER) pathway to study its effects on 8-hydroxy-2′-deoxyguanosine (8-OHdG) excision in the zygote post-fertilization.

Actions biochimiques/physiologiques

X80 is an inhibitor of xeroderma pigmentosum group A protein (XPA protein) required for the removal of all types of DNA lesions repaired by nucleotide excision repair Including both transcription coupled and global genomic nucleotide excision repair.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302,H413

Conseils de prudence

P273 - P301 + P312 + P330

Classification des risques

Acute Tox. 4 Oral - Aquatic Chronic 4

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Xiaoliang Zhang et al.
ACS nano, 11(8), 8478-8487 (2017-08-02)
Colloidal quantum dot (CQD) solar cells have high potential for realizing an efficient and lightweight energy supply for flexible or wearable electronic devices. To achieve highly efficient and flexible CQD solar cells, the electron transport layer (ETL), extracting electrons from
Ian R H Rockett et al.
BMC psychiatry, 10, 35-35 (2010-05-21)
Suicide officially kills approximately 30,000 annually in the United States. Analysis of this leading public health problem is complicated by undercounting. Despite persisting socioeconomic and health disparities, non-Hispanic Blacks and Hispanics register suicide rates less than half that of non-Hispanic
Xiao-Bo Dong et al.
Journal of agricultural and food chemistry, 67(4), 1261-1268 (2019-01-10)
Many organisms possess the ability to produce metal-binding proteins to absorb cadmium. Metallothioneins, an important family of cysteine-rich metal-binding proteins, have been isolated and well characterized. However, Lentinula edodes may have a different type of cadmium-binding protein that contains fewer
Fertilization stimulates 8-hydroxy-2?-deoxyguanosine repair and antioxidant activity to prevent mutagenesis in the embryo
Lord T and Aitken RJ
Developmental Biology, 406(1), 1-13 (2015)
Wendy G Cárdenas-Coronel et al.
Journal of agricultural and food chemistry, 64(1), 302-309 (2015-12-03)
Quality and compositional changes were determined in noni fruit harvested at five ripening stages, from dark-green to thaslucent-grayish. Fruit ripening was accompanied by acidity and soluble solids accumulation but pH diminution, whereas the softening profile presented three differential steps named
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