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WH0000060M1

Sigma-Aldrich

Monoclonal Anti-ACTB antibody produced in mouse

clone 3G4-F9, purified immunoglobulin, buffered aqueous solution

Synonyme(s) :

Anti-actin, beta

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About This Item

Numéro MDL:
MFCD00164531
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Conjugué

unconjugated

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

3G4-F9, monoclonal

Forme

buffered aqueous solution

Espèces réactives

human, rat, mouse

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL

Isotype

IgG1κ

Numéro d'accès GenBank

BC001301

Numéro d'accès UniProt

P60709

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... ACTB(60)

Description générale

Actin β (ACTB) is encoded by the gene mapped to human chromosome 7p22.1. ACTB is a ubiquitously expressed cytoskeletal protein.
This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. (provided by RefSeq)

Immunogène

ACTB (AAH01301, 1 a.a. ~ 375 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MDDDIAALVVDNGSGMCKAGFAGDDAPRAVSPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERRYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF

Application

Monoclonal Anti-ACTB antibody produced in mouse has been used in western blots and immunohistochemistry.

Actions biochimiques/physiologiques

Actin β (ACTB) is an endogenous housekeeping gene. It is extensively used as a reference gene/protein in quantifying expression levels in tumors. Mutation in the gene is associated with the development of Baraitser–Winter cerebrofrontofacial syndrome (BWCFF). Down regulated expression of the gene has been observed in liver, melanoma, renal, colorectal, gastric, pancreatic, esophageal, lung, breast, prostate, ovarian cancers, leukemia and lymphoma.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Solution in phosphate buffered saline, pH 7.4

Informations légales

GenBank is a registered trademark of United States Department of Health and Human Services

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Réf. du produit
Description
Tarif

Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Loss of Igfbp7 Causes Precocious Involution in Lactating Mouse Mammary Gland
Chatterjee S
PLoS ONE, 9 (2014)
Sumanta Chatterjee et al.
PloS one, 9(2), e87858-e87858 (2014-02-08)
Insulin like growth factors (IGFs) and their binding proteins (IGFBPs) are secreted peptides that play major roles in regulating the normal development and maturation of mammary gland. While Igfbp7 has been shown to decrease breast tumor growth, its role in
ACTB in cancer
Guo C
Clinica Chimica Acta; International Journal of Clinical Chemistry, 39-44 (2013)
7p22.1 microduplication syndrome: Clinical and molecular characterization of an adult case and review of the literature
Caselli R
European Journal of Medical Genetics, 58, 578-583 (2015)
Breast Cancers Activate Stromal Fibroblast-Induced Suppression of Progenitors in Adjacent Normal Tissue.
Chatterjee S
Stem Cell Reports, 10, 196-211 (2018)
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