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UC177

(±)-Mephenytoin

Name: (±)-Mephenytoin
Brand: SIGMA

Synonyme(s) :

(±)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione, (±)-5-Ethyl-3-methyl-5-phenylhydantoin

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About This Item

Formule empirique (notation de Hill):

C₁₂H₁₄N₂O₂

Numéro CAS:

50-12-4

Poids moléculaire :

218.25

Numéro CE :

200-012-8

Numéro MDL:

MFCD00022407

Code UNSPSC :

12161501

ID de substance PubChem :

329827653

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Sigma-Aldrich

D127

Dextrorphan tartrate

Forme

crystals

Niveau de qualité

200

Couleur

off-white

Pf

115-118 °C
135-137 °C

Solubilité

DMSO: soluble

Température de stockage

2-8°C

Chaîne SMILES

CCC1(NC(=O)N(C)C1=O)c2ccccc2

InChI

1S/C12H14N2O2/c1-3-12(9-7-5-4-6-8-9)10(15)14(2)11(16)13-12/h4-8H,3H2,1-2H3,(H,13,16)

Clé InChI

GMHKMTDVRCWUDX-UHFFFAOYSA-N

Informations sur le gène

human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

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Actions biochimiques/physiologiques

CYP2B6 and CYP2C19 substrate; anticonvulsive, antiepileptic.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Notes préparatoires

(±)-Mephenytoin is soluble in DMSO.

Pictogrammes

GHS07

Mention d'avertissement

Warning

Mentions de danger

H302,H315,H319,H335

Conseils de prudence

P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Classification des risques

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Identification and characterization of CYP2C18 in the cynomolgus macaque (Macaca fascicularis).

Yasuhiro Uno et al.

The Journal of veterinary medical science, 72(2), 225-228 (2009-11-27)

The macaque is widely used for investigation of drug metabolism due to its evolutionary closeness to the human. However, the genetic backgrounds of drug-metabolizing enzymes have not been fully investigated; therefore, identification and characterization of drug-metabolizing enzyme genes are important

Human pharmacogenetic analysis in chimeric mice with 'humanized livers'.

Yajing Hu et al.

Pharmacogenetics and genomics, 23(2), 78-83 (2012-12-18)

We investigated whether human pharmacogenetic factors could be characterized using chimeric NOG mice expressing a thymidine kinase transgene (TK-NOG) with 'humanized' livers. The rate of human-specific metabolism of two drugs was measured in chimeric mice reconstituted with human hepatocytes with

Development of an in vitro drug-drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds.

Michael Zientek et al.

Journal of pharmacological and toxicological methods, 58(3), 206-214 (2008-07-19)

Inhibition of cytochrome P450 (CYP) is a principal mechanism for metabolism-based drug-drug interactions (DDIs). This article describes a robust, high-throughput CYP-mediated DDI assay using a cocktail of 5 clinically relevant probe substrates with quantification by liquid chromatography/tandem mass spectrometry (LC/MS-MS).

Evaluation of the effects of 20 nonsynonymous single nucleotide polymorphisms of CYP2C19 on S-mephenytoin 4'-hydroxylation and omeprazole 5'-hydroxylation.

Huijuan Wang et al.

Drug metabolism and disposition: the biological fate of chemicals, 39(5), 830-837 (2011-02-18)

CYP2C19 is a highly polymorphic enzyme that affects the metabolism of a wide range of therapeutic drugs. Almost all the identified alleles of CYP2C19 are derived from nonsynonymous single nucleotide polymorphisms (nsSNPs). The objective of this study was to functionally

Generation of mice transgenic for human CYP2C18 and CYP2C19: characterization of the sexually dimorphic gene and enzyme expression.

Susanne Löfgren et al.

Drug metabolism and disposition: the biological fate of chemicals, 36(5), 955-962 (2008-02-16)

CYP2C19 is an important enzyme for human drug metabolism, and it also participates in the metabolism of endogenous substrates, whereas the CYP2C18 enzyme is not expressed in human liver despite high mRNA expression. Mice transgenic for the human CYP2C18 and

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Chromatograms

HPLC Analysis of Mephenytoin Enantiomers on Astec^® CHIROBIOTIC^® V

application for HPLC

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