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Key Documents

U9507

Sigma-Aldrich

Urocortin II mouse

Synonyme(s) :

UCN-II

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About This Item

Numéro CAS:
Numéro MDL:
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.32

Source biologique

mouse

Niveau de qualité

Pureté

≥97% (HPLC)

Forme

solid

Technique(s)

immunohistochemistry: suitable

Numéro d'accès UniProt

Température de stockage

−20°C

Informations sur le gène

mouse ... Ucn2(171530)

Amino Acid Sequence

Val-Ile-Leu-Ser-Leu-Asp-Val-Pro-Ile-Gly-Leu-Leu-Arg-Ile-Leu-Leu-Glu-Gln-Ala-Arg-Tyr-Lys-Ala-Ala-Arg-Asn-Gln-Ala-Ala-Thr-Asn-Ala-Gln-Ile-Leu-Ala-His-Val-NH2

Application

Mouse urocortin II can be used for immunohistochemistry.

Actions biochimiques/physiologiques

Urocortin II is a CRF-related neuropeptide having high affinity for CRF2 receptor. It stimulates protein kinase A through CRF2 receptor and increases the contractility in rabbit ventricular myocytes. It also facilitates pro-inflammatory effects in human intestinal cells through corticotropin-releasing hormone receptor 2α.
corticotropin-releasing factor (CRF) peptide

Autres remarques

Lyophilized from 0.1% TFA in H2O

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)


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Li-Zhen Yang et al.
Cardiovascular research, 69(2), 402-411 (2006-01-03)
Urocortin II (UcnII), a peptide of the corticotropin-releasing factor (CRF) family, exerts profound actions on the cardiovascular system. Direct effects of UcnII on adult cardiomyocytes have not been evaluated before. Our aim was to characterize functional effects of UcnII on
Alan C Moss et al.
Gut, 56(9), 1210-1217 (2007-04-07)
Urocortin II (UcnII) is a neuropeptide that binds with high affinity to the corticotropin-releasing hormone receptor 2 (CRHR2) in peripheral tissues. UcnII is synthesised in the intestine, but its role in human intestinal inflammation is largely unknown. Responses of human
Dimitri Tränkner et al.
Cell reports, 29(4), 791-799 (2019-10-24)
Aberrant microglia activity is associated with many neurological and psychiatric disorders, yet our knowledge about the pathological mechanisms is incomplete. Here, we describe a genetically defined microglia sublineage in mice which has the ability to suppress obsessive compulsion and anxiety symptoms. These
David P Burns et al.
Experimental physiology, 102(9), 1177-1193 (2017-07-01)
What is the central question of this study? We previously reported impaired upper airway dilator muscle function in the mdx mouse model of Duchenne muscular dystrophy (DMD). Our aim was to assess the effect of blocking interleukin-6 receptor signalling and
Patricia Tagliaferro et al.
The Journal of comparative neurology, 506(4), 616-626 (2007-12-11)
Interactions between stress and the mesocorticolimbic dopamine (DA) system have been suggested from behavioral and electrophysiological studies. Because corticotropin-releasing factor (CRF) plays a role in stress responses, we investigated possible interactions between neurons containing CRF and those producing DA in

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