T9826
Anti-TGN38 antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonyme(s) :
Anti-MGC108592, Anti-TGOLN2, Anti-TTGN1, Anti-Trans-golgi network protein 2
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About This Item
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Poids mol.
antigen ~38 kDa
Espèces réactives
rat
Concentration
~1 mg/mL
Technique(s)
indirect immunofluorescence: 5-10 μg/mL using rat NRK cells
Conditions d'expédition
dry ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
rat ... Tgoln1(192152)
Description générale
Trans-Golgi network integral membrane protein 2 (TGOLN2), also known as trans-Golgi network 46 (TGN46), is encoded by the gene mapped to human chromosome 2p11.2. It is a heterodimeric type I integral membrane protein. TGOLN2 has a highly conserved N terminus which consists of a signal peptide. The C terminus comprises part of the lumenal domain, a membrane spanning region and cytoplasmic tail.
Spécificité
Anti-TGN38 recognizes rat TGN38
Immunogène
Synthetic peptide corresponding to amino acid residues of rat TGN38 with C-terminal added cysteine, conjugated to KLH.
Application
Anti-TGN38 antibody produced in rabbit has been used in immunoblotting and immunocytochemistry.
Anti-TGN38 antibody produced in rabbithas been used in
- immunofluorescence
- western blotting
Actions biochimiques/physiologiques
Trans-Golgi network integral membrane protein 2 (TGOLN2) cycles between the trans-Golgi network (TGN) and the cell surface via an early endosomal compartment. This movement is mediated by a tyrosine-based tetra peptide signal (SDYQRL) in the cytoplasmic domain. It plays an important role in the formation of exocytic vesicles at the TGN by functioning as a receptor for complexes of a cytoplasmic protein known as p62 and one GTP-binding protein. The cytoplasmic domain of TGOLN2 binds to the complex and is essential for budding process. It mediates the coupling of the segregation of secretory proteins to the budding of exocytic vesicles. The cytosolic domain of TGOLN2 interacts with AP2 clathrin adaptor complexes and also with the coiled coil region of a protein called neurabin.
Description de la cible
TGN38 (Trans-Golgi network protein, 38-kDa) is a resident integral membrane protein of the trans-Golgi network (TGN), which cycles constitutively between the TGN and the plasma membrane, returning via endosomes.
Forme physique
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Stockage et stabilité
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frostfree” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Produit(s) apparenté(s)
Réf. du produit
Description
Tarif
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Dual RXR motifs regulate nerve growth factor-mediated intracellular retention of the delta opioid receptor
Shiwarski DJ, et al.
Molecular Biology of the Cell, 30(5), 680-690 (2019)
Melkam A Kebede et al.
The Journal of clinical investigation, 124(10), 4240-4256 (2014-08-27)
We previously positionally cloned Sorcs1 as a diabetes quantitative trait locus. Sorcs1 belongs to the Vacuolar protein sorting-10 (Vps10) gene family. In yeast, Vps10 transports enzymes from the trans-Golgi network (TGN) to the vacuole. Whole-body Sorcs1 KO mice, when made
SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed betacells
Kebede MA, et al.
The Journal of Clinical Investigation, 124(10), 4240-4256 (2014)
Joshua Lott et al.
Molecular pharmacology, 101(5), 371-380 (2022-03-04)
The synthetic cannabinoid WIN55,212-2 (WIN) is widely used as a pharmacological tool to study the biologic activity of cannabinoid receptors. In contrast to many other cannabinoid agonists, however, WIN also causes broad effects outside of neurons, such as reducing inflammatory
A PTEN-regulated checkpoint controls surface delivery of delta opioid receptors
Shiwarski DJ, et al.
The Journal of Neuroscience, 37(14), 3741-3752 (2017)
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