Accéder au contenu
MilliporeSigma
Toutes les photos(4)

Key Documents

View All Documentation

T1001

Sigma-Aldrich

Thyroglobulin from bovine thyroid

powder, ≥90% (agarose gel electrophoresis)

Synonyme(s) :

Globulins thyro, Thyractin

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(4)

About This Item

Numéro CAS:
9010-34-8
Numéro CE :
232-721-3
Numéro MDL:
MFCD00132429
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.61

Source biologique

bovine thyroid

Niveau de qualité

200

Pureté

≥90% (agarose gel electrophoresis)

Forme

powder

Poids mol.

~670 kDa

Composition

Iodine, ≥0.20%

Dosage de l'azote

13.0-16.0% total

Cendres

≤4%

Solubilité

H2O: 20 mg/mL

Numéro d'accès UniProt

P01267

Température de stockage

−20°C

Informations sur le gène

cow ... TG(280706)

Vous recherchez des produits similaires ? Visite Guide de comparaison des produits

Application

Bovine thyroglobulin was shown to stimulate proliferation in rat thyroid follicular cells as well as in primary porcine thyroid epithelial cells. This effect was mediated through PI3K signaling.
Often used as a carrier protein for the production of antibodies. Its advantage is the large number of tyrosine residues that can be used for conjugation using the diazo reaction.

Actions biochimiques/physiologiques

Bovine thyroglobulin is a large, tetrameric glycoprotein produced in the thyroid gland as a precursor to thyroid hormones. Its large size and absence from plasma under normal conditions makes it very immunogenic and reduces the chance that antibodies to this carrier protein will cross-react with plasma proteins in immunoassays. Haptens may be conjugated to thyroglobulin via accessible secondary amines.
Iodine-containing protein that is stored in the thyroid gland. Converted into circulating thyroxines when the thyroid is stimulated by thyroid-stimulating hormone (TSH) from the pituitary. Because its expression is unique to the thyroid, it is a sensitive indicator of recurrence or metastasis of thyroid cancer that has been treated by thyroid ablation.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Mahsa Hadidi et al.
Biotechnology progress, 32(6), 1531-1538 (2016-10-22)
Charged polysaccharides are used in the food industry, as cosmetics, and as vaccines. The viscosity, thermodynamics, and hydrodynamic properties of these charged polysaccharides are known to be strongly dependent on the solution ionic strength because of both inter- and intramolecular
N Murat Karabacak et al.
Molecular & cellular proteomics : MCP, 8(4), 846-856 (2008-12-17)
Top-down and bottom-up mass spectrometry methods can generate gas phase fragments and use these to identify proteins. Top-down methods, in addition, can provide the mass of the protein itself and therefore additional structural information. Despite the conceptual advantage of top-down
Laura Gámez-Díaz et al.
Immunology and cell biology, 95(9), 789-802 (2017-06-28)
Biallelic mutations in the human lipopolysaccharide responsive beige-like anchor (LRBA) gene lead to a primary immunodeficiency known as LRBA deficiency, characterized by a broad range of clinical manifestations including autoimmunity, organomegaly, hypogammaglobulinemia and recurrent infections. Considering the phenotypic heterogeneity in
William H Fissell et al.
Journal of membrane science, 326(1), 58-63 (2010-01-08)
Silicon micromachining provides the precise control of nanoscale features that can be fundamentally enabling for miniaturized, implantable medical devices. Concerns have been raised regarding blood biocompatibility of silicon-based materials and their application to hemodialysis and hemofiltration. A high-performance ultrathin hemofiltration
Jonathan Friedman et al.
Nature ecology & evolution, 1(5), 109-109 (2017-08-16)
Microorganisms typically form diverse communities of interacting species, whose activities have tremendous impact on the plants, animals and humans they associate with. The ability to predict the structure of these complex communities is crucial to understanding and managing them. Here
Afficher tous les articles scientifiques apparentés

Articles

A validated amino acid analysis assay for accurate quantification of stable isotope labeled protein reference materials: SIL thyroglobulin case study

With the emergence of mass spectrometry for the clinical measurement of proteins in biological matrices, the development of biological reference materials will continue to grow in importance.

HPLC Analysis of Proteins on Zenix® SEC-300, 30 cm x 7.8 mm I.D., 3 μM

Separation of null

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique