SRP8059

Jagged-2 (human): FC (human)

recombinant, expressed in HEK 293 cells, ≥90% (SDS-PAGE)

• Synonyme(s) : Alpha-ketoglutarate-dependent dioxygenase FTO, Protein jagged-2, hJ2
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.32

Propriétés

• Produit recombinant: expressed in HEK 293 cells
• Pureté: ≥90% (SDS-PAGE)
• Forme: lyophilized
• Poids mol.: ~150 kDa by SDS-PAGE
• Impuretés: <0.1 EU/μgtested
• Numéro d'accès UniProt: Q9Y219
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Informations sur le gène: human ... JAG2(3714)

Description

Description générale

Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-kappaB and C-myc to promote the proliferation and to inhibit the apoptosis of MM cells, showing in the relationship between the incidence of myeloma and drug resistance. Jagged-2 is also involved in limb development.

Séquence

Human Jagged-2 (aa 1-1054) is fused at the C-terminus to the Fc portion of human IgG.

Forme physique

Lyophilized. Contains PBS + 0.02 % CHAPS.

Reconstitution

Reconstitute with 100μl sterile water.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable