SRP8049
Periostin mouse
recombinant, expressed in CHO cells, FLAG® tagged, >95% (SDS-PAGE)
Synonyme(s) :
OSF-2, Osteoblast-specific factor 2, PC cell-derived growth factor
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About This Item
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.32
Produits recommandés
Source biologique
mouse
Produit recombinant
expressed in CHO cells
Étiquette/Marqueur
FLAG® tagged
Pureté
>95% (SDS-PAGE)
Forme
lyophilized
Poids mol.
~85 kDa
Conditionnement
pkg of 10 μg
Conditions de stockage
avoid repeated freeze/thaw cycles
Impuretés
<0.1 EU/μg endotoxin, tested
Couleur
white
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Informations sur le gène
mouse ... Postn(50706)
Description générale
Periostin (POSTN) is also called as osteoblast-specific factor 2. It is a matricellular protein, located in the alveolar walls. This gene is located on human chromosome 13q13.
Periostin was originally isolated as a osteoblast-specific factor that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Additionally, periostin expression has previously been shown to be significantly increased by both transforming growth factor beta1 (TGF-beta1) and bone morphogenetic protein (BMP-2). Abnormal expression of periostin is also linked to angiogenesis and metastasis in epithelial tumors.
Actions biochimiques/physiologiques
Periostin (POSTN) participates in collagen fibrillogenesis. It plays a major role in the development of scar after traumatic spinal cord injury (SCI). Periostin controls the activities of fibrocyte to stimulate myofibroblast differentiation and lung fibrosis. It modulates the amount of collagen in tissue. Periostin also participates in the assembly of the extracellular matrix (ECM) architecture.
Forme physique
Lyophilized from PBS.
Reconstitution
Reconstitute with 100 μL deionized water.
Autres remarques
Mouse periostin (aa 24-783) (isoform 5) is fused at the C-terminus to a FLAG®-tag.
Informations légales
FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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Periostin promotes scar formation through the interaction between pericytes and infiltrating monocytes/macrophages after spinal cord injury.
Yokota K, et al.
The American Journal of Pathology, 187(3), 639-653 (2017)
Periostin regulates fibrocyte function to promote myofibroblast differentiation and lung fibrosis.
Ashley SL, et al.
Mucosal Immunology, 10(2), 341?351-341?351 (2017)
A K Devrim et al.
Bratislavske lekarske listy, 118(11), 705-709 (2017-12-09)
Although the molecular mechanism of cardiac healing is not fully understood, myocardial infarction is one of the most usual diagnoses in hospitalized patients in industrialized nations while periostin has been recently suggested to have a potential in tissue repairing following
R Nakajima et al.
The British journal of dermatology, 178(6), 1373-1382 (2017-12-15)
Interleukin (IL)-25 is a member of the IL-17 family, which can promote and augment T-helper (Th) type 2 responses. The expression of IL-25 and its cognate receptor, IL-25 receptor (IL-25R), is upregulated and correlated with disease activity in Th2-associated diseases.
Jin Ho Hwang et al.
American journal of nephrology, 46(6), 501-517 (2017-12-22)
Periostin is responsible for tissue regeneration, fibrosis, and wound healing via its interaction with integrin. Recently, the role of periostin has been shown to contribute to fibrosis in chronic kidney disease. We investigated the role of periostin and the effect
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