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Key Documents

SRP6257

Sigma-Aldrich

ADIPOQ/Adiponectin/ACRP30 human

recombinant, expressed in HEK 293 cells, ≥92% (SDS-PAGE)

Synonyme(s) :

ACDC, ACRP30, ADIPOQ, APM1, Adiponectin, GBP28

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About This Item

Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

Source biologique

human

Produit recombinant

expressed in HEK 293 cells

Étiquette/Marqueur

6-His tagged (C-terminus)

Pureté

≥92% (SDS-PAGE)

Forme

lyophilized powder

Poids mol.

calculated mol wt 25.4 kDa
observed mol wt 28-33 kDa (DTT-reduced. Protein migrates due to glycosylation. Glu 19 is the predicted N-terminus.)

Conditionnement

pkg of 10 μg

Impuretés

<1 EU/μg endotoxin (LAL test)

Numéro d'accès UniProt

Q15848

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

human ... ADIPOQ(9370)

Description générale

Adiponectin (also called Acrp30, AdipoQ) is an adipocyte specific secreted protein that circulates in the plasma. It is induced during adipocyte differentiation and its secretion is stimulated by insulin. The protein has a carboxyl-terminal globular domain and an amino-terminal collagen domain. The gene is mapped to human chromosome 3q27.

Actions biochimiques/physiologiques

Adiponectin (ADIPOQ) has anti-atherosclerotic and anti-inflammatory properties. ADIPOQ has a role in physiological processes such as energy homeostasis and obesity. It exhibits anti-diabetic action by interacting with adiponectin receptors, AdipoR1 and AdipoR2. Low levels of adiponectin are also linked with hypertension and dyslipidemia. Mutation in the gene encoding it is linked with risk for endometrial cancer.

Forme physique

Lyophilized from 0.22 μm filtered solution in PBS. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Effects of MCF2L2, ADIPOQ and SOX2 genetic polymorphisms on the development of nephropathy in type 1 Diabetes Mellitus.
Zhang D, et al.
BMC Medical Genetics, 11, 116-116 (2010)
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients.
Hotta K, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 20(6), 1595-1599 (2000)
Genetic architecture of the APM1 gene and its influence on adiponectin plasma levels and parameters of the metabolic syndrome in 1,727 healthy Caucasians.
Heid I M, et al.
Diabetes, 55(2), 375-384 (2006)
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome.
Kadowaki T, et al.
The Journal of Clinical Investigation, 116(7), 1784-1792 (2006)
Association Between Single Nucleotide Polymorphism +276G > T (rs1501299) in ADIPOQ and Endometrial Cancer.
Bienkiewicz J, et al.
Pathology Oncology Research, 22(1), 135-138 (2016)
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