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Key Documents

SRP6156

Sigma-Aldrich

BMP-4 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Synonyme(s) :

BMP-2B, Bone morphogenetic protein 2B, Bone morphogenetic protein 4

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About This Item

Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

Source biologique

human

Produit recombinant

expressed in HEK 293 cells

Pureté

≥95% (SDS-PAGE)

Forme

lyophilized

Puissance

2-10 ng/mL

Poids mol.

34 kDa (homodimer, glycosylated.)

Conditionnement

pkg of 10 μg

Conditions de stockage

avoid repeated freeze/thaw cycles

Impuretés

<1 EU/μg protein Endotoxin level (LAL test)

Numéro d'accès NCBI

P12644

Conditions d'expédition

dry ice

Température de stockage

−20°C

Informations sur le gène

human ... BMP4(652)

Catégories apparentées

Description générale

BMP4 (bone morphogenetic protein 4), a member of the highly conserved BMP family, is a growth factor and a pro-inflammatory and pro-atherogenic cytokine. BMPs are part of the TGFβ (tumor growth factor) superfamily of proteins. BMP4 gene is localized to human chromosome 14q22-q23.

Actions biochimiques/physiologiques

BMP4 (bone morphogenetic protein 4) is involved in modulating cell development in a wide variety of cells. It promotes the proliferation and migration of hepatocellular carcinoma cells, and the multiplication of ALK3 (activin-like kinase)-positive cells in skeletal muscle. This protein prevents the proliferation of lung fibroblasts and induces their differentiation into myocytes. In Sertoli cells, it promotes DNA synthesis and hence, the proliferation of Sertoli cells through Smad1/5 (small mothers against decapentaplegic) and ID2/3 (DNA binding protein inhibitor) pathway, and aberration in BMP4 expression results in azoospermia. In human males, the serum levels of BMP4 is linked with coronary artery disease (CAD) severity. BMP4 is crucial for maintaining the self-renewal capacity of ES (embryonic stem) cells, and achieves so by inhibiting extracellular receptor kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) pathways.

Forme physique

Lyophilized from a PBS solution.

Notes préparatoires

Centrifuge the vial prior to opening.

Reconstitution

Reconstitute in sterile 4 mM HCl containing 0.1% endotoxin-free recombinant human serum albumin.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Bmp4 is required for the generation of primordial germ cells in the mouse embryo.
Lawson KA et al
Genes & Development, 13(4), 424-436 (1999)
BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways.
Qi X et al
Proceedings of the National Academy of Sciences of the USA, 101(16), 6027-6032 (2004)
Serum Bone Morphogenic Protein-4 Contributes to Discriminating Coronary Artery Disease Severity.
Park CS et al
Medicine, 94(3), e1530-e1530 (2015)
Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis.
Weaver M et al
Development, 127(12), 2695-2704 (2000)
BMP4 promotes human Sertoli cell proliferation via Smad1/5 and ID2/3 pathway and its abnormality is associated with azoospermia.
Hai Y et al
Discovery Medicine, 19(105), 311-325 (2015)
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