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Key Documents

SRP6007

Sigma-Aldrich

NT-3 from mouse

recombinant, expressed in E. coli, ≥97% (SDS-PAGE), ≥97% (HPLC)

Synonyme(s) :

HDNF, NGF-2, NT-3, Nerve growth factor-2, Neurotrophic factor

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About This Item

Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

Source biologique

mouse

Produit recombinant

expressed in E. coli

Pureté

≥97% (HPLC)
≥97% (SDS-PAGE)

Forme

lyophilized

Poids mol.

13.6 kDa

Conditionnement

pkg of 10 μg

Impuretés

Endotoxin, tested

Numéro d'accès NCBI

P20181

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

mouse ... NTF3(18205)

Description générale

NT-3 (neurotrophin-3) is a member of the family of trophic factors, called neurotrophins. This family also includes NGF (nerve growth factor), BDNF (brain-derived neurotrophic factor), and NT-4. NT-3 is the most abundantly expressed neurotrophin during early development.
Murine NT-3 produced from Escherichia coli contains 119 amino acid and having a molecular mass is 13.6kDa.

Application

NT-3 (neurotrophin-3) has been used for the ex vivo treatment of skin punches obtained from rat and human samples.

Actions biochimiques/physiologiques

Study in mice show that NT-3 (neurotrophin-3), along with BDNF (brain-derived neurotrohpic factor), is essential for inner ear development. In vitro motor, enteric, primary sensory, sympathetic, locus coeruleus, cerebellar and hippocampal neurons are responsive to NT-3. Mice null for NT-3 show significant deficiency in sympathetic and sensory nerve populations. In mice, post birth up-regulation of NT-3 induces a second wave of dopaminergic amacrine cell genesis.

Forme physique

Sterile filtered and lyophilized powder

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in H?O to a concentration of 0.1-1.0 mg/ml.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Development of a pharmacodynamic biomarker to measure target engagement from inhibition of the NGF-TrkA pathway.
Price EA et al
Journal of Neuroscience Methods, 282, 34-42 (2017)
Complementary roles of BDNF and NT-3 in vestibular and auditory development.
Ernfors P et al
Neuron, 14(6), 1153-1164 (1995)
Overexpression of neurotrophin-3 stimulates a second wave of dopaminergic amacrine cell genesis after birth in the mouse retina.
Yoshida M et al
The Journal of Neuroscience, 31(35), 12663-12673 (2011)
Severe sensory and sympathetic deficits in mice lacking neurotrophin-3.
Fari?as I et al
Nature, 369(6482), 658-661 (1994)
Shyan-Yuan Kao et al.
Bone, 145, 115837-115837 (2021-01-02)
The bone encasing the inner ear, known as the otic capsule, is unique because it remodels little postnatally compared to other bones in the body. Previous studies established that osteoprotegerin (OPG) in the inner ear inhibits otic capsule remodeling. OPG
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