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SRP5187

HSD17B10, GST tagged human

Name: HSD17B10, GST tagged human
Brand: SIGMA

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonyme(s) :

17b-HSD10, ABAD, ERAB, HADH2, HCD2, MHBD, SCHAD

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About This Item

Numéro CAS:

1608128-07-9

Code UNSPSC :

12352202

Nomenclature NACRES :

NA.32

Source biologique

human

Produit recombinant

expressed in baculovirus infected Sf9 cells

Pureté

≥70% (SDS-PAGE)

Forme

buffered aqueous glycerol solution

Poids mol.

~51 kDa

Numéro d'accès NCBI

NM_004493

Application(s)

cell analysis

Conditions d'expédition

dry ice

Température de stockage

−70°C

Informations sur le gène

human ... HSD17B10(3028)

Description générale

HSD17B10 gene encodes the protein 17-beta-hydroxysteroid dehydrogenase 10 that is a member of the short-chain dehydrogenase/reductase superfamily SCHAD. HSD17B10 gene product is a mitochondrial protein that is involved in lipid metabolism, fatty acid oxidation and steroid hormone metabolism. HSD17B10 protein has been implicated in the development of Alzheimer′s disease and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD). Furthermore, HSD17B10 may act as a direct molecular link between beta-amyloid and mitochondrial toxicity.

Forme physique

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Notes préparatoires

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.

Joyce W Lustbader et al.

Science (New York, N.Y.), 304(5669), 448-452 (2004-04-17)

Mitochondrial dysfunction is a hallmark of beta-amyloid (Abeta)-induced neuronal toxicity in Alzheimer's disease (AD). Here, we demonstrate that Abeta-binding alcohol dehydrogenase (ABAD) is a direct molecular link from Abeta to mitochondrial toxicity. Abeta interacts with ABAD in the mitochondria of

Multiple functions of type 10 17beta-hydroxysteroid dehydrogenase.

Song-Yu Yang et al.

Trends in endocrinology and metabolism: TEM, 16(4), 167-175 (2005-04-30)

Human 17beta-hydroxysteroid dehydrogenase type 10 (17beta-HSD10) is a mitochondrial enzyme encoded by the SCHAD gene, which escapes chromosome X inactivation. 17Beta-HSD10/SCHAD mutations cause a spectrum of clinical conditions, from mild mental retardation to progressive infantile neurodegeneration. 17Beta-HSD10/SCHAD is essential for

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