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Key Documents

SRP4915

Sigma-Aldrich

Vaspin human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥90% (HPLC)

Synonyme(s) :

OL-64, SERPINA12, Serpin A12 precursor, Vaspin, Visceral adipose tissue- derived serine protease inhibitor, Visceral adipose-specific serpin

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About This Item

Code UNSPSC :
12352200
Nomenclature NACRES :
NA.32

Source biologique

human

Produit recombinant

expressed in E. coli

Pureté

≥90% (HPLC)
≥90% (SDS-PAGE)

Forme

lyophilized powder

Poids mol.

~47.0 kDa

Conditionnement

pkg of 25 μg

Conditions de stockage

avoid repeated freeze/thaw cycles

Impuretés

endotoxin, tested

Numéro d'accès NCBI

Q8IW75

Conditions d'expédition

dry ice

Température de stockage

−70°C

Informations sur le gène

human ... SPA12(145264)

Description générale

Vaspin (visceral adipose-specific SERPIN), a newly identified adipokine, is a member of serine protease inhibitor family. It is also known as serpin family A member 12 (SERPINA12). The gene encoding this protein is localized on human chromosome 14q32.13. Recombinant human Vaspin produced in E. coli is a single, non-glycosylated polypeptide chain containing 415 amino acids and having a molecular mass of 47kDa.

Actions biochimiques/physiologiques

Vaspin (visceral adipose-specific SERPIN) is also a unique insulin sensitizing adipocytokine in obesity. A recent publication indicates that induction of human vaspin mRNA expression in adipose tissue is regulated in a fat depot-specific manner and could be associated with parameters of obesity, insulin resistance, and glucose metabolism. This protein may be useful as a biomarker with patients with acute myocardial infarction. It is a ligand of the 78kDa glucose-regulated protein/murine transmembrane protein (GRP78/MTJ-1) complex and has indirect effects on endoplasmic reticulum stress-induced metabolic disorders.

Forme physique

1 mg/ml in 20 mM Tris pH-8, 0.2 mM PMSF and 10% glycerol.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

nwg

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Feihong Yang et al.
Biochemical and biophysical research communications, 503(2), 501-507 (2018-05-08)
Visceral adipose tissue-derived serine protease inhibitor (vaspin), as a secretory adipokine, was reported to exert a protective role on insulin resistance. Recent studies showed that serum vaspin level was downregulated in patients with coronary artery disease. However, whether vaspin exerted
Vaspin as a Prognostic Marker in Patients with Acute Myocardial Infarction.
Zhang B
Heart, Lung & Circulation, 25(3), 257-264 (2016)
Vaspin: a novel adipokine, member of the family of serine protease inhibitors
Ekaterini Koiou
Aristotle University Medical Journal, 38.3, 7-18 (2011)
The role of vaspin in the development of metabolic and glucose tolerance disorders and atherosclerosis.
Dimova R and Tankova T
BioMed Research International, 823481-823481 (2015)
Association between vaspin level and coronary artery disease in patients with type 2 diabetes.
Hao F
Diabetes Research and Clinical Practice, 113, 26-32 (2016)
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