SRP0702

SORAFENIB

recombinant

• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: >95% (TLC)
• Forme: lyophilized powder
• Poids mol.: ~464.8
• Conditions d'expédition: ambient
• Température de stockage: −20°C

Description

Application

Clinically useful anticancer agent.

Actions biochimiques/physiologiques

Initially developed as a Raf kinase inhibitor, IC50 = 6 nM, but has been shown to inhibit many receptor tyrosine kinases including BRAF (IC50 = 22 nM); VEGFR-2 (IC50 = 90 nM); VEGFR-3 (IC50 = 20 nM); PDGFR-beta (IC50 = 57 nM); Flt3 (IC50 = 58 nM); c-KIT (IC50 = 68 nM); FGFR-1 (IC50 = 580 nM) ⁽¹⁾. Paradoxically more potent in a cellular assay (IC50 = 20 nM) compared to an isolated enzyme assay (IC50 = 107 nM) for c-Fms ⁽²⁾. Inhibits activation of MAPK pathway and ERK phosphorylation ⁽³⁾. Induces caspase-independent apoptosis in melanoma cells ⁽⁴⁾.

Reconstitution

Formulated as a lyophilized powder. May be dissolved in DMSO (200 mg/mL) or Ethanol (3 mg/mL).

Stockage et stabilité

Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H360FD,H362,H372,H410
• Conseils de prudence: P202 - P260 - P263 - P264 - P273 - P308 + P313
• Classification des risques: Aquatic Acute 1 - Aquatic Chronic 1 - Lact. - Repr. 1B - STOT RE 1
• Code de la classe de stockage: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable