SRP0570

5′-NUCLEOTIDASE/CD73, His-Tag

recombinant, expressed in HEK 293 cells

• Synonyme(s) : 5′- nucleotidase, Ecto-5′-nucleotidase
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.26

Propriétés

• Produit recombinant: expressed in HEK 293 cells
• Forme: frozen liquid
• Poids mol.: 58.6 kDa
• Numéro d'accès UniProt: P21589
• Conditions d'expédition: dry ice
• Température de stockage: −70°C
• Informations sur le gène: human ... NT5E(4907)

Description

Description générale

5′-Nucleotidase/CD73 is glycosyl-phosphatidyl inositol (GPI)- anchored cell surface protein. Itis present in various tissues and cells including endothelial cells, epithelialcells, and subsets of B and T cells.

Application

5′-Nucleotidase/CD73 has been used as a standard in recombinanthuman CD73 assay.

Actions biochimiques/physiologiques

5′-Nucleotidase/CD73 actsas a rate-limiting enzyme to produce adenosine. It helps in upholding tissuehomeostasis by converting the adenosine triphosphate (ATP)-triggered immuneactivation to adenosine-mediated immunosuppression.CD73 is a novel immunoinhibitory protein that participates in tumor growthand metastasis. CD73 in combination with conventional therapy and/or otherimmune checkpoint inhibitors has been reported to show therapeutic effectsagainst cancer.

Forme physique

Aqueous solution

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319
• Conseils de prudence: P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2
• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable