SML3596

Losmapimod

≥98% (HPLC)

• Synonyme(s) : 6-[5-(Cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)nicotinamide, 6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide, 6-{5-[(cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl}-N-(2,2-dimethylpropyl)-3-pyridinecarboxamide, CID 11552706, GSK-AHAB, GW856553X, SB 856553
• Formule empirique (notation de Hill): C₂₂H₂₆FN₃O₂
• Numéro CAS: 585543-15-3
• Poids moléculaire : 383.46
• Numéro MDL: MFCD16619322
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 2 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C(NCC(C)(C)C)C1=CC=C(C2=C(C)C(F)=CC(C(NC3CC3)=O)=C2)N=C1
• InChI: 1S/C22H26FN3O2/c1-13-17(9-15(10-18(13)23)21(28)26-16-6-7-16)19-8-5-14(11-24-19)20(27)25-12-22(2,3)4/h5,8-11,16H,6-7,12H2,1-4H3,(H,25,27)(H,26,28)
• Clé InChI: KKYABQBFGDZVNQ-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

Losmapimod is a potent and selective inhibitor of the p38 mitogen-activated protein kinases (MAPK) family. In SHR-SP rats losmapimod improves survival, endothelial-dependent and -independent vascular relaxation. Also losmapimod attenuates dyslipidemia, hypertension, cardiac remodeling, plasma renin activity (PRA), aldosterone, and interleukin-1 (IL-1 ). Losmapimod produces antidepressant and antipsychotic effects.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable