SML2608

CSRM617 Hydrochloride

≥98% (HPLC)

• Synonyme(s) : (2,3,4-Trihydroxyphenyl-methylidene)-hydrazino-2-amino-3-hydroxy-1-propanone hydrochloride, 2-Amino-3-hydroxy-N′-(2,3,4-trihydroxybenzylidene)propanehydrazide hydrochloride, 2-[(2,3,4-trihydroxyphenyl)methylene] serinehydrazide hydrochloride (1:1)
• Formule empirique (notation de Hill) : C₁₀H₁₃N₃O₅ · HCl
• Numéro CAS: 1353749-74-2
• Poids moléculaire : 291.69
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to beige
• Solubilité: H₂O: 2 mg/mL, clear
• Température de stockage: −20°C
• Chaîne SMILES: OC1=C(C=CC(O)=C1O)C=NNC(C(CO)N)=O.Cl
• Clé InChI: YBUPSOQAGSOATG-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

CSRM617 is an ONECUT2 (OC2) inhibitor that directly targets OC2 HOX domain (KD = 7.43 μM) and disrupts OC2 target genes promoter binding. CSRM617 blocks OC2-dependent prostate cancer growth in cultures (IC50 = 4-50 μM; 48 h) via apoptosis induction (fold of untreated annexin V population = 2.3/10 μM, 3.5/20 μM; 22Rv1) and exhibits in vivo efficacy against metastases as well as the growth of established 22Rv1 tumor in mice in vivo (50 mg/kg/day ip.).

HOX domain-targeting ONECUT2 (OC2) inhibitor against OC2-dependent prostate cancer growth in vitro and in vivo.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H317,H319,H341,H410
• Conseils de prudence: P201 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Classification des risques: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Muta. 2 - Skin Sens. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable