SML1516

DS-437

≥98% (HPLC)

• Synonyme(s) : 5′-S-[2-[[(Ethylamino)carbonyl]amino]ethyl]-5′-thio-adenosine
• Formule empirique (notation de Hill): C₁₅H₂₃N₇O₄S
• Numéro CAS: 1674364-87-4
• Poids moléculaire : 397.45
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825933
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 20 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CSCCNC(NCC)=O)O3
• InChI: 1S/C15H23N7O4S/c1-2-17-15(25)18-3-4-27-5-8-10(23)11(24)14(26-8)22-7-21-9-12(16)19-6-20-13(9)22/h6-8,10-11,14,23-24H,2-5H2,1H3,(H2,16,19,20)(H2,17,18,25)/t8-,10+,11?,14-/m1/s1
• Clé InChI: CACMCLIHCDTJHL-XNZUMOJTSA-N

Description

Application

DS-437 has been used as an inhibitor of protein arginine methyltransferase 5 (PRMT5) to study its effect on forkhead box P3 (FOXP3) methylation and regulatory T cells (Tregs) function in 293T cells.

Actions biochimiques/physiologiques

DS-437 inhibits regulatory T cells (Tregs) function and methylation of forkhead box P3 (FOXP3) in 293T cells. DS-437 in combination with anti-p185erbB2/neu antibody 4D5 reduces tumor growth in CT26HER2 tumor-bearing mice.

DS-437 is an analog of S-adenosyl methionine (SAM ), which inhibits protein arginine methyltransferases PRMT5 and PRMT7 (IC₅₀ 5.9 and 6 μM) with little interaction against a panel of 30 other human methyltransferases.

Autres remarques

DS-437 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the DS-437 probe summary on the Chemical Probes Portal website.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301
• Conseils de prudence: P264 - P270 - P301 + P310 - P405 - P501
• Classification des risques: Acute Tox. 3 Oral
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable